TLDR Hormonal treatments effectively manage acne in some women, especially with specific hormonal issues.
The document discussed the role of hormones, particularly androgens, in the development of acne vulgaris and the use of hormonal therapies as an effective treatment option for selected female patients. It highlighted that the severity of acne and the presence of any endocrinologic pathology influenced treatment decisions. Hormonal therapies, including ovarian and adrenal androgen production suppressors, androgen receptor blockers, 5-alpha-reductase inhibitors, and insulin sensitizers, were used, with combined oral contraceptives being the most preferred. These therapies were particularly suitable for women with menstrual irregularities, premenstrual acne exacerbation, late-onset acne, ovarian or adrenal hyperandrogenism, or acne concentrated in the lower face, especially the chin, and for those who could not use or did not respond to conventional therapies.
5 citations
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May 2017 in “Current Opinion in Pediatrics” Hormonal therapies are safe and effective for treating acne in female adolescents, with specific treatments for those with endocrine disorders.
10 citations
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January 2017 in “Dermatology Online Journal” Metformin helps treat moderate-to-severe acne when used with other treatments.
46 citations
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September 2016 in “Clinical, Cosmetic and Investigational Dermatology” Hormonal treatments are effective for severe or persistent acne and should be used with other acne therapies, considering potential side effects.
31 citations
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June 2015 in “British Journal of Dermatology” Hormonal treatments are effective as a second-line option for moderate-to-severe acne in females, but should be used with caution due to health risks.
9 citations
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April 2015 in “Dermatologic Therapy” Hormonal therapies, like flutamide and cyproterone acetate, are safe and effective for treating adult women's acne, especially those with hormone imbalance or resistant acne.
5 citations
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December 2014 in “Medicine and Pharmacy Reports” Ciproterone acetate improves hair regrowth and acne in most female patients.
8 citations
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January 1996 in “Gynecological Endocrinology” Cyproterone acetate is the preferred treatment for women's hyperandrogenism when estrogen/progestogen use is safe.
131 citations
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September 2017 in “Molecular and Cellular Endocrinology” The document concludes that blocking the internal pathways that create androgens might help treat cancers that depend on sex hormones.
21 citations
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November 2022 in “Frontiers in immunology” Sebaceous glands play a key role in skin health, immunity, and various skin diseases.
12 citations
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December 2012 in “Current Drug Targets” The Androgen Receptor could be a target for treating diseases like cancer, but more research is needed to confirm the effectiveness of potential treatments.
research Acne
81 citations
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January 2002 in “American journal of clinical dermatology” Hormonal treatments can help with acne, especially in women, by lowering androgen levels or blocking their effects.
