Aggressive Treatment in Pediatric Patients With Drug-Induced Hypersensitivity Syndrome/Drug Reaction With Eosinophilia and Systemic Symptoms Is Associated With Future Development of Type III Polyglandular Autoimmune Syndrome

    October 2018 in “ BMJ Case Reports ”
    Chiyo Morita, Tetsuji Yanase, Tetsuo Shiohara, Yumi Aoyama
    TLDR Aggressive treatment in young patients with certain drug reactions may lead to multiple autoimmune diseases later.
    The study discussed a 6-year-old boy with drug-induced hypersensitivity syndrome (DiHS)/drug reaction with eosinophilia and systemic symptoms (DRESS) who developed type III polyglandular autoimmune syndrome (PASIII) following aggressive treatment with intravenous immunoglobulin (IVIG) and prednisolone. A literature review identified five similar cases, suggesting that while these treatments were effective short-term, they might increase the risk of long-term autoimmune issues in pediatric patients. The study recommended careful screening for autoantibodies and advised against therapies that could hasten immune recovery, potentially leading to PASIII.
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