Recent Advances in Multiple Strategies for the Biosynthesis of Sesquiterpenols

The review highlights recent advancements in the biosynthesis of sesquiterpenols, emphasizing the use of synthetic biology and metabolic engineering to improve production efficiency and sustainability. Traditional methods face challenges like low yields, but microbial systems, particularly yeast, offer promising alternatives. Key strategies include optimizing biosynthetic pathways, enhancing enzyme activity, and improving microbial tolerance to terpenoid toxicity. The document discusses the diverse applications of sesquiterpenols, such as antimicrobial and anticancer properties, and details enzyme engineering techniques and metabolic regulation to enhance production. Future research directions focus on overcoming challenges in large-scale production through interdisciplinary approaches and advancements in synthetic and systems biology.