Management of Adolescent Polycystic Ovary Syndrome
TLDR SPIOMET therapy may be a promising alternative to oral contraceptives for treating adolescent PCOS.
Polycystic ovary syndrome (PCOS) in adolescents is increasingly prevalent and challenging to diagnose due to overlapping symptoms with normal puberty. The International evidence-based guideline (2018) suggests using the Rotterdam criteria, excluding polycystic ovarian morphology, with definitions adjusted for age at menarche. Treatment often relies on adult guidelines, but a combination therapy of spironolactone, pioglitazone, and metformin (SPIOMET) shows promise as an alternative to oral contraceptives. The appropriate duration of treatment remains uncertain, highlighting the need for prospective studies and well-designed randomized controlled trials to improve management strategies for adolescent PCOS.
