Clinical Value of Adipose Tissue-Derived Stem Cells Application in Healing of Experimental Diabetic and Nondiabetic Burns

August 2018 in “ Ibnosina Journal of Medicine and Biomedical Sciences ”

Randa Hana, Heba A. Yassa

adipose tissue-derived stem cells collagen deposition angiogenesis KGF-1 Serpin B3 fat-derived stem cells keratinocyte growth factor 1

TLDR Adipose tissue-derived stem cells effectively improve burn healing, especially in diabetics.

The study investigated the effects of adipose tissue-derived stem cells on healing third-degree burns in both diabetic and nondiabetic mice. Forty male mice were divided into four groups, including diabetic and nondiabetic groups treated with these stem cells. Results showed that the stem cells accelerated burn healing, enhanced collagen deposition, angiogenesis, and increased expression of keratinocyte growth factor-1 (KGF-1). Additionally, hair growth was observed in the stem cell-treated groups. The study concluded that adipose tissue-derived stem cells were effective in treating burns, particularly in diabetic cases, with Serpin B3 and KGF-1 serving as valuable biomarkers for successful healing.

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