The Effect of Adipose-Derived Stem Cell Exosomes on the Biological Activity of Dermal Papilla Cells

April 2022 in “ DOAJ (DOAJ: Directory of Open Access Journals) ”

Tang Xin, Cuixiang CAO, Yunxiao Liang, Min Liu, Miao-Jian Wan, Tang Xin, Cuixiang CAO, Yunxiao Liang, Min Liu, Miao-Jian Wan

adipose-derived stem cell exosomes dermal papilla cells hair growth cell proliferation Versican alkaline phosphatase hair follicle inducibility ADSC-Exos DPCs

TLDR Adipose-derived stem cell exosomes can boost hair growth by enhancing dermal papilla cell activity.

The study investigated the effects of adipose-derived stem cell exosomes (ADSC-Exos) on the biological activity of dermal papilla cells (DPCs) and their potential impact on hair growth. ADSCs were cultured, and exosomes were isolated and characterized. When ADSC-Exos were co-cultured with DPCs, there was a significant increase in cell viability compared to the control group, as indicated by the CCK-8 test (P<0.05). Additionally, Western blot analysis showed higher expression levels of Versican and alkaline phosphatase (ALP) in the exosome group (P<0.05). The study concluded that ADSC-Exos could promote DPC proliferation and enhance their hair follicle inducibility.

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