Optimizing Clinical Monitoring and Management Guidelines for Capivasertib in HR-Positive/HER2-Negative Advanced Breast Cancer: Expert Opinion

    December 2025 in “ npj Breast Cancer
    Neil M. Iyengar, Joyce O’Shaughnessy, Heather Moore, Erika Hamilton, Komal Jhaveri, X. Cynthia, Karen L. Tedesco, Monali Vasekar, Sarah Donahue, Hope S. Rugo
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    Studysummary In the phase 3 CAPItello-291 trial, capivasertib combined with fulvestrant significantly increased progression-free survival in patients with advanced breast cancer with specific genetic alterations, but the authors highlight that managing side effects like diarrhea, rash, and hyperglycemia is crucial for optimizing treatment adherence and outcomes.
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