Transcriptomic Crossroads: Decoding Genes and Pathways That Connect Alopecia Areata With Chronic Inflammatory Skin Disorders

    May 2026 in “ JID Innovations ”
    Hadis Abdolahzadeh, Sabrina Henne, Amir Mokhlesi … F B Basmanav
    Studysummary This study found a significant overlap between gene expression signatures of alopecia areata and certain chronic inflammatory skin disorders, suggesting shared biological processes may drive their co-occurrence and providing a foundation for future research into distinct comorbid subtypes.
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    Research cited in this study 7

    1. Comorbid Bronchial Asthma, Atopic Dermatitis, and Hashimoto's Thyroiditis Are Risk Factors for Early-Onset, Severe, and Prolonged Alopecia Areata Allergy · 2025
    2. Alopecia Areata: The Clinician and Patient Voice Journal of drugs in dermatology · 2023
    3. Comorbid Conditions Associated With Alopecia Areata: A Systematic Review and Meta-Analysis American Journal of Clinical Dermatology · 2023
    4. Aberrant Inflammasome Activation as a Driving Force of Human Autoimmune Skin Disease Frontiers in immunology · 2023
    5. Alopecia Areata and Risk of Atopic and Autoimmune Conditions: Population-Based Cohort Study Clinical and Experimental Dermatology · 2022
    6. Immunological Properties of Atopic Dermatitis-Associated Alopecia Areata International Journal of Molecular Sciences · 2021
    7. Comorbidities in Alopecia Areata: A Systematic Review and Meta-Analysis Journal of The American Academy of Dermatology · 2018