Chemical Constituents of Halophyte Suaeda Glauca and Their Therapeutic Potential for Hair Loss

January 2024 in “ Molecules/Molecules online/Molecules annual ”

Yunna Kim, Min-Gyu Park, Yu-Jung Kim, Jae-Sun Lee, Bong-Oh Kwon, Jung‐Rae Rho, Eunju Jeong

Suaeda glauca alkaloids flavonoids phenolics human follicle dermal papilla cells HFDPCs human umbilical vein endothelial cells HUVECs kaempferol VEGF IGF-1 Wnt/β-catenin signaling minoxidil vascular endothelial growth factor insulin-like growth factor 1 Wnt signaling Rogaine

From the encyclopedia

Vascular Endothelial Growth Factor →

Minoxidil →

An essential vasodilator with some anti-androgenic effects

Studysummary In this study, researchers identified eight compounds in Suaeda glauca and reported that its extract may improve hair loss by affecting VEGF, IGF-1 expression, and Wnt/β-catenin signaling, especially compound 4, in human cell models.

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The study investigated the therapeutic potential of compounds isolated from the halophyte Suaeda glauca for hair loss. Eight compounds, including alkaloids, flavonoids, and phenolics, were identified and tested on human follicle dermal papilla cells (HFDPCs) and human umbilical vein endothelial cells (HUVECs). The extract and isolated compounds, particularly kaempferol, significantly increased the expression of VEGF, IGF-1, and regulated Wnt/β-catenin signaling, showing activity comparable to or better than minoxidil. These findings suggest that S. glauca and its compounds could be promising candidates for preventing or treating hair loss.

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