Human Type 3 5α-Reductase Is Expressed in Peripheral Tissues at Higher Levels Than Types 1 and 2 and Its Activity Is Potently Inhibited by Finasteride and Dutasteride

August 2010 in “ Hormone Molecular Biology and Clinical Investigation ”

Kazutoshi Yamana, Fernand Labrie, Van Luu-The

type 3 5α-reductase type 1 5α-reductase type 2 5α-reductase finasteride dutasteride androgen metabolism androgen-related disorders Propecia Avodart

From the encyclopedia

Finasteride →

Frontline, gold standard treatment for combatting androgenic alopecia

Dutasteride →

Heavy duty finasteride that comes with higher risks

Studysummary This study found that SRD5a-3 is a highly efficient enzyme for converting hormones into androgens, with dutasteride being a much more potent inhibitor of SRD5a-3 than SRD5a-2.

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