Lrig1 Expression Confers Suppressive Function to CD4+ Cells and Is Essential for Averting Autoimmunity via the Smad2/3/Foxp3 Axis

    September 2023 in “ Nature Communications ”
    Jae‐Seung Moon, Chun-Chang Ho, Jong‐Hyun Park, Kyungsoo Park, Boyoung Shin, Su-Hyeon Lee, Su-Hyeon Lee, Inês Sequeira, Chin Hee Mun, Jin-Su Shin, Beom Seok Kim, Beom Seok Kim, Jin-Wook Noh, Eui-Seon Lee, Ji Young Son, Yuna Kim, Yeji lee, Hee Cho, SunHyeon So, Jiyoon Park, Eun-Su Choi, Jong‐Won Oh, Sang-Won Lee, Sang-Won Lee, Tomohiro Morio, Fiona M. Watt, Rho Hyun Seong, Sang‐Kyou Lee, Sang‐Kyou Lee
    Studysummary In this study, researchers found that the cell surface protein Lrig1 plays a crucial role in regulating the suppressive function of regulatory T cells, suggesting it as a potential target for treating autoimmune diseases, as evidenced by experiments in mouse models.
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