Plasma and Sonophoresis-Assisted Topical Delivery of an Exosome for Androgenic Alopecia

April 2026 in “ Journal of Craniofacial Surgery ”

Olena Sydorchuk, Ruri Pamela, Massimo Vitale, Dagné Pupo, Nam Seok, Suyeon Lee, Kyu-Ho Yi

plasma-assisted delivery sonophoresis-assisted delivery exosome androgenic alopecia hair growth scalp health

Studysummary This pilot study found that plasma- and sonophoresis-assisted delivery of an exosome-containing formulation improved hair and scalp metrics over 12 weeks, with short-term safety observed, but controlled trials are needed for confirmation.

Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer

This 12-week pilot study investigated the effects of plasma and sonophoresis-assisted delivery of an exosome-containing topical formulation on androgenetic alopecia in 25 adults. The treatment led to significant improvements in hair density, increasing from 165.3 to 182.5 hairs/cm², and hair shaft diameter, which grew from 48.7 to 52.1 µm. The terminal-to-vellus hair ratio also improved, and scalp sebum levels and inflammation scores decreased. Photographic assessments showed hair growth improvement in 72% of participants, and 68% reported satisfaction with the treatment. Mild, transient erythema was the only reported adverse effect. The study suggests potential benefits of this treatment, but controlled trials are necessary to confirm its efficacy and the specific impact of the delivery methods.

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