Structural and Molecular Hair Abnormalities in Trichothiodystrophy

    May 2006 in “ ˜The œjournal of investigative dermatology/Journal of investigative dermatology ”
    Christine Liang, Andrea Morris, Sebastian Schlücker, Kyoko Imoto, Vera H. Price, Emory Menefee, Stephen Wincovitch, Ira W. Levin, Deborah Tamura, Katrin R Strehle, Kenneth H. Kraemer, John J. DiGiovanna
    Studysummary In this study, researchers found that trichothiodystrophy hair brittleness is linked to abnormalities in sulfur content and structural organization, making it prone to breakage.
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    The study on "Structural and Molecular Hair Abnormalities in Trichothiodystrophy" examined hair from 15 patients with trichothiodystrophy (TTD) and identified several structural abnormalities, including tiger tail banding, trichoschisis, and trichorrhexis nodosa. Using various microscopic techniques, researchers found an inverse correlation (Rval=0.9) between sulfur content and hair abnormalities, indicating that lower sulfur levels led to weaker hair. Raman spectroscopy revealed a higher presence of less stable disulfide conformers in TTD hair. The findings suggested that TTD hair brittleness was due to multiple structural and molecular abnormalities, making it prone to breakage and weathering.
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