Appropriateness of Oral Drugs for Long-Term Treatment of Lower Urinary Tract Symptoms in Older Persons: Results of a Systematic Literature Review and International Consensus Validation Process (LUTS-FORTA 2014)

    June 2015 in “ Age and Ageing ”
    Matthias Oelke, Klaus Becher, David Castro‐Díaz, Emmanuel Chartier‐Kastler, Mike Kirby, Adrian Wagg, Martin Wehling
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    Studysummary This study classified dutasteride, fesoterodine, and finasteride as beneficial for older or frail elderly patients, while suggesting caution or avoidance of α-blockers and antimuscarinics in this group.
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    The study systematically reviewed the appropriateness of oral drugs for long-term treatment of lower urinary tract symptoms (LUTS) in older adults, using the FORTA classification system. It found that no drugs were indispensable (FORTA A), but dutasteride, fesoterodine, and finasteride were beneficial (FORTA B) due to their efficacy and lack of significant side effects. Most drugs, particularly α-blockers and antimuscarinics, were rated as requiring caution (FORTA C) or advised against (FORTA D) due to potential adverse effects like cardiovascular risks. The study emphasized the need for more targeted research on drug safety and efficacy in the elderly population.
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