TLDR Dual therapy with specific medications can help manage male urinary symptoms and reduce side effects.
The document discussed guidelines for the primary care management of male lower urinary tract symptoms (LUTS), highlighting the potential benefits of dual therapy with a 5α-reductase inhibitor and an alpha-adrenergic blocker to reduce the risk of side effects from benign prostatic hyperplasia (BPH), such as urinary retention. It also mentioned a randomized placebo-controlled study on the use of finasteride for chronic nonbacterial prostatitis, emphasizing the need for cautious evaluation of treatments due to the lack of comparative trials. Additionally, the document noted ongoing interest in the epidemiology and severity grading of LUTS symptoms like frequency and nocturia.
1707 citations
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December 2003 in “The New England Journal of Medicine” Combination therapy of doxazosin and finasteride safely and effectively reduces benign prostatic hyperplasia progression risk.
1054 citations
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February 1998 in “The New England Journal of Medicine” Finasteride reduces urinary issues and surgery need in men with enlarged prostates by over 50%.
35 citations
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May 2020 in “Frontiers in Pharmacology” Different drugs for prostate-related urinary symptoms work but have various side effects, and treatment should be tailored to the individual.
15 citations
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July 2016 in “Urologic Clinics of North America” Finasteride and dutasteride are effective for long-term treatment of enlarged prostates but have sexual side effects and a risk of high-grade prostate cancer.
15 citations
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November 2015 in “Pharmacopsychiatry” α-Blockers and 5-ARIs for BPH can cause sexual dysfunction, including erectile and ejaculatory issues.
34 citations
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January 1998 in “European Urology” Finasteride works best in 6 months and lasts 6 years.
14 citations
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November 2006 in “Current Medicinal Chemistry” New treatments for enlarged prostate are being developed to be more effective and have fewer side effects.