Guideline for the Primary Care Management of Male Lower Urinary Tract Symptoms

    May 2004 in “ British Journal of Urology
    Mark J. Speakman, Roger Kirby, A.D. Joyce, Paul Abrams, Richard Pocock
    TLDR Dual therapy with specific medications can help manage male urinary symptoms and reduce side effects.
    The document discussed guidelines for the primary care management of male lower urinary tract symptoms (LUTS), highlighting the potential benefits of dual therapy with a 5α-reductase inhibitor and an alpha-adrenergic blocker to reduce the risk of side effects from benign prostatic hyperplasia (BPH), such as urinary retention. It also mentioned a randomized placebo-controlled study on the use of finasteride for chronic nonbacterial prostatitis, emphasizing the need for cautious evaluation of treatments due to the lack of comparative trials. Additionally, the document noted ongoing interest in the epidemiology and severity grading of LUTS symptoms like frequency and nocturia.
    Discuss this study in the Community →

    Research cited in this study

    2 / 2 results

    Related Community Posts Join

    6 / 180 results

      community The truth about Dutasteride (w/ sources)

      in Finasteride/Dutasteride  52 upvotes 3 years ago
      The effectiveness of Dutasteride compared to Finasteride in treating hair loss, with evidence given such as studies and experiences, as well as discussion around whether one should switch from Finasteride to Dutasteride. There is also a discussion on post-Dutasteride syndrome.
      FCE 28260: A Forgotten 5α-Reductase Inhibitor

      community FCE 28260: A Forgotten 5α-Reductase Inhibitor

      in Research  330 upvotes 1 year ago
      FCE 28260 (PNU 156765), an under-explored 5α-reductase inhibitor, showcases promising results in research by Giudici et al., outperforming well-known treatments like Finasteride in reducing the conversion of testosterone to DHT. Its superior efficacy, demonstrated through lower IC50 values in both natural and human recombinant enzyme studies, suggests it could offer more effective management of DHT-related conditions. Additionally, its lower molecular weight hints at better potential for topical application, potentially offering advantages in treating conditions such as androgenic alopecia. Despite its potential, it has not advanced in development, possibly due to financial limitations, leaving its therapeutic prospects and side effect profile largely unexplored.

      community Blood DHT Levels – before and after creatine

      in Research/Science  41 upvotes 3 years ago
      The impact of creatine on DHT levels, and whether it could cause accelerated male pattern baldness (MPB). The user taking a 5 alpha reductase inhibitor found that their DHT levels actually reduced despite taking creatine for nine weeks. Replies suggested looking into testosterone levels as well and debating the safety of creatine use in relation to MPB.
      Can I still save my hairline at age of 15?

      community Can I still save my hairline at age of 15?

      in General  532 upvotes 4 months ago
      A 15-year-old is concerned about hair loss, possibly at Norwood 2 or 3, and is using shampoos and conditioners recommended by a trichologist. Suggestions include considering topical minoxidil and consulting a doctor about topical anti-DHT treatments like finasteride or RU58841, but avoiding 5-alpha-reductase inhibitors at this age.

      community NW5 at 19. How many grafts do I need?

      in Transplants  139 upvotes 2 years ago
      A 19-year-old with rapid hair loss since 16 is considering a hair transplant but refuses to take finasteride or any 5α-Reductase inhibitors. They are currently using minoxidil, tretinoin, and microneedling with a Derminator 2, and only want hair until age 27.

    Similar Research

    5 / 1000+ results