Three-Dimensional Imaging of Tight Junction Network Across Multiple Layers of Human Epidermis by Array Tomography Using Backscattered Electron-Mode Scanning Electron Microscopy

August 2019 in “ Journal of Investigative Dermatology ”

Akemi Ishida‐Yamamoto, Yusuke Nagasawa, Hiroshi Yamanishi, Mari Kishibe, Atsushi Miyaki, Satoshi Kusumi, Tsuyoshi Watanabe, Daisuke Koga

epidermal turnover keratinocyte proliferation epidermal differentiation markers desmoplakin epidermal morphogenesis PPARs Ppara gene expression skin barrier integrity microbial diversity BP180 Dsg1 degradation tight junctions stratum granulosum skin turnover skin cell proliferation skin differentiation markers skin structure skin barrier skin microbes skin protein skin layers

Studysummary This study found that tight junctions extend to the most superficial layer of the stratum granulosum in human skin, challenging previous claims of their limited presence in the epidermis.

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