Integrated Single-Cell RNA-Sequencing Data of Unwounded and Wounded Mouse Skin and Fibroblasts

This study does not report results but provides integrated single-cell RNA sequencing data from multiple mouse wound healing models, offering resources for studying fibroblast-driven changes in the extracellular matrix and signaling during the healing process.

This study found that wounding in skin induces significant fibroblast heterogeneity and recruits myeloid cells, which contribute to adipocyte regeneration in mice.

This study used single-cell RNA-sequencing data from mouse skin to reveal that fibroblasts show high transcriptional plasticity during wound healing, forming transient microniches early on and stratifying scar tissue into distinct molecular layers over time.

In this study, researchers using single nuclei RNA-sequencing found that fibroblasts in deeper layers of mouse skin expressed higher levels of pro-inflammatory genes post-wounding compared to other cells, highlighting their significant role in early inflammation and tissue repair processes.

In this study, researchers found that wound healing in mouse skin recruits diverse fibroblasts, including myeloid-derived cells, which contribute to regenerating adipocytes.