Prenatal Transplantation of Epidermal Neural Crest Stem Cells in Malformation of Cortical Development Mouse Model

    December 2016 in “ Microscopy Research and Technique ”
    Abdollah Omidi, Mohammad Esmaeil Akbari, Keywan Mortezaee, Ehsan Eqlimi, Cordian Beyer, Adib Zendedel, Iraj Ragerdi Kashani
    Studysummary This study suggests that prenatal infusion of epidermal neural crest stem cells may improve certain neural markers and reduce cortical injury in a mouse model of methylazoxymethanol-induced malformations.
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    The study investigated the potential of prenatal transplantation of epidermal neural crest stem cells (EPI-NCSCs) derived from hair follicles in treating malformations of cortical development (MCD) in a mouse model. Mice exposed to methylazoxymethanol (MAM) showed reduced thickness in various cerebral cortex areas and the corpus callosum. However, prenatal infusion of EPI-NCSCs led to a significant increase in cortical thickness, except for the corpus callosum. Real-time PCR and immunohistochemistry analyses indicated altered expression of neural and glial markers, suggesting that EPI-NCSCs could be a promising candidate for cell-based therapy of cortical injuries by influencing neural markers and their interaction with glial cells.
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