Phospholipase C-δ1 Is an Essential Molecule Downstream of Foxn1, the Gene Responsible for the Nude Mutation, in Normal Hair Development

October 2007 in “ The FASEB Journal ”

Yoshikazu Nakamura, Manabu Ichinohe, Masayuki Hirata, Hirokazu Matsuura, Takashi Fujiwara, Takahiro Igarashi, Masamichi Nakahara, Hideki Yamaguchi, Sadao Yasugi, Tadaomi Takenawa, Kiyoko Fukami

phospholipase C-δ1 PLC-δ1 Foxn1 nude mutation hair keratins hair development

Studysummary This study suggests that hairlessness in nude mice may be due to insufficient expression of phospholipase C-δ1, a molecule essential for normal hair development downstream of the Foxn1 gene.

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research Defining BMP Functions in the Hair Follicle by Conditional Ablation of BMP Receptor IA

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Phospholipase Cδ1 is crucial for normal skin and hair development.

research HOXC13 Is Involved in the Regulation of Human Hair Keratin Gene Expression

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This study demonstrated that HOXC13 directly influences hair keratin gene expression by binding to specific DNA motifs, suggesting its role in early hair follicle differentiation.

research Inhibition of BMP Signaling Affects Growth and Differentiation in the Anagen Hair Follicle

305 citations , December 2000 in “The EMBO Journal”

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research Forkhead/Winged-Helix Transcription Factor Whn Regulates Hair Keratin Gene Expression: Molecular Analysis of the Nude Skin Phenotype

75 citations , April 2000 in “Developmental Dynamics”

This study suggests that the structural integrity and physical proximity of Whn's DNA binding and activation domains are crucial for hair keratin gene activation and may explain the nude phenotype.

research Whn and mHa3 Are Components of the Genetic Hierarchy Controlling Hair Follicle Differentiation

79 citations , December 1999 in “Mechanisms of Development”

Whn is crucial for hair growth in certain areas by controlling a specific gene.

research Multiple Roles for Activated LEF/TCF Transcription Complexes During Hair Follicle Development and Differentiation

990 citations , October 1999 in “Development”

This study found that LEF1/TCF3 is necessary but not sufficient for TOPGAL activation in hair follicle development, indicating complex regulation in the skin.

Hoxc13 Mutant Mice Lack External Hair

research Hoxc13 Mutant Mice Lack External Hair

245 citations , January 1998 in “Genes & Development”

This study found that Hoxc13 mutations in mice cause defects in hair, nail, and tongue structures, with the most noticeable issue being brittle hair leading to alopecia.