Hair Follicles Guide Nerve Migration In Vitro and In Vivo in Tissue-Engineered Skin

March 2011 in “ Journal of Investigative Dermatology ”

Vicky Gagnon, Danielle Larouche, Rémi Parenteau‐Bareil, Marie Gingras, Lucie Germain, François Berthod

hair follicles tissue-engineered skin nerve migration reinnervation hair bud-like structures iTES-HBLS nerve fibers skin grafts

Studysummary Hair follicles help guide nerve growth, improving touch recovery in skin grafts.

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research Tissue-Engineered Skin Preserving the Potential of Epithelial Cells to Differentiate into Hair After Grafting

24 citations , October 2010 in “Tissue Engineering Part A”

This study found that tissue-engineered skin using mouse fibroblasts successfully supported hair growth after grafting, but similar success was not observed using human fibroblast-derived tissue.

research Activation of Beta-Catenin Signaling Programs Embryonic Epidermis to Hair Follicle Fate

193 citations , May 2008 in “Development”

This study found that activating β-catenin signaling in embryonic epidermis promoted hair follicle characteristics at the expense of normal epidermal differentiation, leading to early pigmentation and innervation.

research Developmental Timing of Hair Follicle and Dorsal Skin Innervation in Mice

86 citations , May 2002 in “Journal of comparative neurology”

This study observed that hair follicle innervation in C57BL/6 mice occurs in sequential stages that closely correlate with the development of hair follicles, indicating an interdependent relationship between neuronal and epithelial morphogenesis.