Regulation of Masculinization: Androgen Signaling for External Genitalia Development

April 2018 in “ Nature Reviews Urology ”

Shoko Matsushita, Kentaro Suzuki, Aki Murashima, Daiki Kajioka, Alvin R. Acebedo, Shinichi Miyagawa, Ryuma Haraguchi, Yukiko Ogino, Gen Yamada

androgen signaling androgen receptor testosterone dihydrotestosterone DHT MAFB Wnt-ß-catenin endocrine-disrupting chemicals EDCs hypospadias genital development masculinization

Studysummary This review discusses the molecular mechanisms of masculinization involving androgen signaling and their roles in male embryonic development and conditions like hypospadias and prostate cancer, and reports no clinical results.

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