Scalp Biopsy and Diagnosis of Common Hair Loss Problems

July 2013 in “ InTech eBooks ”

Khitam Al-Refu

scalp biopsy scarring alopecias non-scarring alopecias 4-mm punch subcutaneous fat histological examination vertical sections horizontal sections specific staining techniques discoid lupus erythematosus lichen planopilaris alopecia areata peribulbar lymphocytic inflammation telogen hairs androgenetic alopecia terminal to vellus hair ratio

Studysummary This article reviews the differences between scarring and non-scarring alopecias and describes diagnostic methods but reports no new clinical findings.

Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer

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research Basement Membrane Changes in Lichen Planopilaris

7 citations , June 2009 in “Journal of the European Academy of Dermatology and Venereology”

This study found that in lichen planopilaris, the basement membrane zone of the hair follicles exhibited disrupted and discontinuous staining patterns, potentially contributing to scarring and irreversible hair loss.

research A Comparison of Vertical Versus Transverse Sections in the Evaluation of Alopecia Biopsy Specimens

56 citations , July 2005 in “Journal of The American Academy of Dermatology”

This study found that vertical sections of alopecia biopsy specimens had a higher concordance rate with the original combined diagnosis compared to transverse sections alone, although both methods have their pros and cons.

research Eosinophils in Fibrous Tracts and Near Hair Bulbs: A Helpful Diagnostic Feature of Alopecia Areata

64 citations , July 1997 in “Journal of The American Academy of Dermatology”

This study found that eosinophils are a useful diagnostic feature for alopecia areata, especially when the typical "swarm of bees" lymphoid infiltrate is absent, helping differentiate it from trichotillomania.

research The Pathogenesis of Alopecia Areata

89 citations , October 1996 in “Dermatologic Clinics”

This review discusses androgenetic alopecia and alopecia areata through a systems biology lens, emphasizing the role of multi-omics data integration to explore molecular mechanisms and potential therapeutic strategies, but offers no new clinical results.

research Diagnostic and Predictive Value of Horizontal Sections of Scalp Biopsy Specimens in Male Pattern Androgenetic Alopecia

309 citations , May 1993 in “Journal of The American Academy of Dermatology”

This study concluded that horizontal sections of scalp biopsy specimens provide more diagnostic information for male pattern androgenetic alopecia than vertical sections and can predict hair regrowth potential following topical minoxidil therapy.