Spatiotemporal Dynamics of Sensory Neuron and Merkel-Cell Remodeling During Epidermal Homeostasis

February 2023 in “ bioRxiv (Cold Spring Harbor Laboratory) ”

Rachel C. Clary, Blair A. Jenkins, Ellen A. Lumpkin

Merkel cells sensory axons epidermal homeostasis hair regeneration depolarization agent Bouton axon terminals transgenic mouse lines two-photon imaging

Preprint — not peer reviewed. This was posted to a preprint server or data repository. It has not been through a journal's review process, and its findings may change or not hold up.

Studysummary This study found that in adult mouse skin, somatosensory axon plasticity is highly dynamic and influenced by epithelial-neural crosstalk and intrinsic neural mechanisms.

Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer

View this study on biorxiv.org →

Discuss this study in the Community →

Research cited in this study

5 / 5 results

research The Cellular Basis of Mechanosensory Merkel-Cell Innervation During Development

32 citations , February 2019 in “eLife”

This study identified key cells and pathways needed for the development of touch receptor patterns in mouse skin, notably that certain keratinocytes are crucial for innervation patterns, while Merkel cells and BMP signaling have distinct roles.

research Touch Receptors Undergo Rapid Remodeling in Healthy Skin

31 citations , November 2016 in “Cell Reports”

This study reveals that somatosensory neurons in mouse skin exhibit structural plasticity during hair-follicle regeneration, which may temporarily impair the reliability of encoding gentle touch.

research Dynamic Plasticity of Axons Within a Cutaneous Milieu

79 citations , November 2010 in “Journal of Neuroscience”

In this study, researchers found that simple hair clipping in mice induced dynamic plasticity and axogenesis in skin sensory axons, linked to follicular activation and HGF signaling.

research Epidermal Homeostasis: A Balancing Act of Stem Cells in the Skin

1039 citations , February 2009 in “Nature Reviews Molecular Cell Biology”

This review discusses the reuse of molecular mechanisms involved in embryonic skin development for maintaining adult epidermal homeostasis and reports no new results.

research Hair-Cycle-Associated Remodeling of the Peptidergic Innervation of Murine Skin and Hair Growth Modulation by Neuropeptides

112 citations , February 2001 in “Journal of Investigative Dermatology”

This study found that substance P and calcitonin-gene-related peptide have different roles in regulating hair growth in mice, with substance P promoting anagen progression and calcitonin-gene-related peptide inhibiting it.