11β-Hydroxysteroid Dehydrogenase Type 1 Inhibition Attenuates the Adverse Effects of Glucocorticoids on Dermal Papilla Cells
September 2017
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Studysummary This study explores the expression and function of 11β-HSD1 in human hair follicles and its potential regulation of glucocorticoid effects on dermal papilla cells, but reports no definitive findings on 11β-HSD1's role.
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The study from September 15, 2017, found that 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1), a regulator of glucocorticoid availability, is expressed in human dermal papilla cells (DPCs). Glucocorticoids, which are stress-related hormones, were found to inhibit hair growth by decreasing cellular proliferation and the expression of Wnt5a, ALP, and VEGF in DPCs. However, the use of an 11β-HSD1 inhibitor significantly reduced these negative effects of glucocorticoids on DPCs. This suggests that 11β-HSD1 inhibitors could potentially be used to treat stress-related hair loss.
