Sodium Divalproate in Low Alternating Daily Doses for Migraine Prevention: A Retrospective Study
July 2019
in “
Headache The Journal of Head and Face Pain
”
Studysummary This study suggests that low alternating daily doses of sodium divalproate may be effective for migraine prevention, similarly to higher doses, but can still lead to modest weight gain.
Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer
The retrospective study evaluated the use of sodium divalproate (SD) in low alternating daily doses for migraine prevention in 68 patients from a tertiary center. The study found that the average headache frequency decreased from 8.2 to 5.1 days per month after 2 months, with an adherence rate of 73.5%, and further reduced to 4.2 days per month at 4 months, with an adherence rate of 61.8%. However, weight gain was a side effect, reported by 30% of patients at 2 months and 42.8% at 4 months. Despite the study's limitations, such as its retrospective design, the findings suggested that low alternating doses of SD might be effective, though controlled studies were needed for confirmation.
