피부장벽, 이온, 사이토카인

The document discussed the importance of the Ca2+ gradient in skin development and wound healing, highlighting its role in epidermal permeability barrier formation during fetal development. It was noted that the Ca2+ gradient regulates lamellar body secretion independently of barrier formation. Studies on mice showed that the absence of the calcium-sensing receptor (CaR) led to abnormalities in epidermal development, while overexpression of CaR resulted in early barrier formation and enhanced differentiation markers. CaR was identified as a critical sensor of the epidermal Ca2+ gradient, essential for keratinocyte differentiation and migration.