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research A 56-Day Randomized, Double-Blinded, and Placebo-Controlled Clinical Assessment of Scalp Health and Hair Growth Parameters with a Centella asiatica Extracellular Vesicle and Growth Factor-Based Essence

September 2025 in “medRxiv (Cold Spring Harbor Laboratory)”

This study found that applying a topical scalp essence with Centella asiatica extracellular vesicles and growth factors significantly improved scalp health and hair growth compared to a placebo after 56 days.

research A Review on Multipurpose Hair Shampoo, Serum and Conditioner in Sigle Trio Pack

March 2026 in “Zenodo (CERN European Organization for Nuclear Research)”

This study aims to create and evaluate a novel trio pack of polyherbal hair care products, that includes a shampoo, conditioner, and serum, leveraging diverse botanical extracts known for promoting hair growth and scalp health, while reducing side effects typical of chemical-based cosmetics.

research Evaluation of ozonated oil and centella asiatica extract on excisional wound healing in Mice

January 2026 in “Revista Científica de la Facultad de Ciencias Veterinarias”

This study concluded that both ozonated oil and Centella asiatica extract effectively accelerated wound healing in mice through different mechanisms, with the former enhancing early-stage inflammation and the latter promoting collagen deposition and regenerative healing.

research Dermatological drugs, topical agents, and cosmetics

1 citations , January 2005 in “Side effects of drugs annual”

This chapter reviews various dermatological drugs and treatments, highlighting adverse effects, with no new clinical findings reported.

research Dermatological drugs and topical agents

January 2004 in “Side effects of drugs annual”

Certain skin drugs and topical agents, including some natural extracts and fragrances, can cause allergic reactions. Some hair dyes and extensions, as well as minoxidil, a hair growth treatment, can also cause allergies. Botulinum toxin A can effectively reduce sweat but may have temporary side effects.

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Learn

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learn Centella

Can a centella (gotu kola) supplement help hair loss from a poor diet? What the evidence says There is no published human trial showing that an oral Centella asiatica (gotu kola) supplement stops hair shedding caused by poor nutrition; the evidence is laboratory work on dermal papilla cells, inflammation and collagen, and community reports mention centella only in topical products.

learn Finasteride

Topical or oral? Choosing between pills and lotions according to your case. In studies, topical finasteride gave much lower blood levels of the drug than tablets but still lowered blood DHT, and whether it causes fewer side effects has not been established. There is no FDA-approved topical finasteride, and the FDA warned about compounded versions in April 2025.

learn Cetirizine

Is topical cetirizine effective for androgenetic alopecia in women? Topical cetirizine is not an approved product and its use for female-pattern hair loss is off-label. The evidence is one small pilot study in mixed-sex patients and one randomized trial in 66 women where cetirizine was added to minoxidil; it is unproven on its own.

learn Glycerin

Does topical glycerin have any effect on hair thickness or follicle function? Topical glycerin mainly hydrates the hair and scalp; no study has shown that it increases hair thickness or changes follicle function.

learn Valproic acid

How is valproic acid being explored differently in topical hair products compared to its traditional oral medical use? Topical valproic acid is being studied for local effects on the hair follicle rather than the whole-body effects of the oral drug. The human evidence is one small randomized 24-week trial of an 8.3% spray; no topical valproate product is approved for hair loss.

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Community Join

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community Plant based hair growth serum shows visible results in <2 months. What do you think?

1 upvotes 11 months ago

A plant-based hair growth serum using Centella shows visible results in less than 2 months with minimal side effects. It is considered a promising alternative to conventional treatments like Minoxidil and finasteride.

community Serum based on plant extracts boosts hair growth in weeks.

44 upvotes 11 months ago

A serum containing Centella asiatica extracellular vesicles, IGF-1, FGF-7, and caffeine significantly improved hair thickness, density, length, and reduced hair loss after 56 days. The conversation also discusses how treatments like finasteride, minoxidil, and ketoconazole address different aspects of hair loss by reducing DHT, improving blood flow, and lowering inflammation.

community New plant-based serum shown to regrow hair in weeks, according to scientists

in Treatment 274 upvotes 9 months ago

A new plant-based serum is claimed to regrow hair in weeks, but users are skeptical about its effectiveness and the reliability of the study. Ingredients like Centella Asiatica and IGF-1 are mentioned, but many doubt the serum's superiority over existing treatments like Minoxidil and finasteride.

community Scientists have uncovered a simple way to cure hair loss – as incredible before–and–after photos show the results in just 8 weeks

in Research/Science 283 upvotes 11 months ago

Scientists claim a combination of caffeine, two proteins, and Centella asiatica extracts can cure hair loss, but skepticism remains due to past unfulfilled promises. Users discuss various treatments like minoxidil, finasteride, and microneedling, expressing doubt about the effectiveness of new methods.

community Best science-backed supplements for androgenetic alopecia? Looking for real evidence

7 months ago

The conversation discusses treatments for androgenetic alopecia, focusing on evidence-based supplements to complement finasteride. Suggestions include oral minoxidil, saw palmetto, pumpkin seed oil, tocotrienols, and various other supplements, while emphasizing the importance of scientific backing and cautioning against saw palmetto if already using finasteride.

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Experts

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Clinics

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