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research Tributyltin (TBT) effects on Ocinebrina aciculata (Gastropoda: Muricidae): imposex development, sterilization, sex change and population decline

156 citations , October 1996 in “Science of The Total Environment”

This study observed that tributyltin pollution induces imposex, reduces reproductive success, and leads to population decline in Ocinebrina aciculata, highlighting its sensitivity compared to other prosobranch species.

research Disruptors of Androgen Action and Synthesis

1 citations , January 2015 in “Elsevier eBooks”

This review discusses the potential antiandrogenic effects of environmental chemicals on reproductive development, highlighting concerns about their impacts on humans but reports no new clinical findings.

research Female Antiandrogens

1 citations , October 2017 in “Elsevier eBooks”

This review examines the effects of antiandrogens on female reproductive systems, particularly regarding environmental endocrine disruptors, and presents no new research findings.

research Androgen Biosynthesis Inhibitors and Androgen Receptor Antagonists

January 2004 in “Elsevier eBooks”

This article discusses drugs with anti-androgenic effects and their mechanisms but reports no new research findings.

research Discovery of Nonsteroidal Androgens

209 citations , March 1998 in “Biochemical and biophysical research communications”

This study identified a novel class of nonsteroidal ligands that can mimic the effects of dihydrotestosterone on androgen receptors, suggesting potential therapeutic applications in male fertility and hormone replacement therapy.

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Learn

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learn Cyproterone

a synthetic anti-androgen and weak progestogen that inhibits DHT binding to androgen receptor

learn dehydroepiandrosterone

learn GT20029

Experimental topical drug designed to break down androgen receptors

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Community Join

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community What are some topical anti androgens(not dht).

3 upvotes 3 months ago

The conversation is about exploring topical anti-androgens for hair loss, specifically mentioning Bicalutamide and the unpleasant smell of Spironolactone. RU58841 is unavailable, and Breezula is suggested as an alternative.

community Everyone seems to be looking for an antiandrogen as an add on. But what about Estradiol & its derivatives ( excluding the low concentraion alfatradiool ) being used. Anyone has an experience with this ? Anything that won't cause feminization in the process ?

5 upvotes 2 years ago

The conversation discusses using estradiol and its derivatives for hair loss without causing feminization. Users mention alternatives like alfatradiol, topical 17b-Estradiol, and DIM (Diindolylmethane).

community KX-826 and RU58841: do topical anti-androgens work?

10 upvotes 3 weeks ago

KX-826 and RU58841 are topical anti-androgens discussed for hair loss prevention, with KX-826 showing promise in trials and RU58841 having mixed anecdotal results. Users report combining these with treatments like minoxidil, finasteride, and dutasteride, with varying success and concerns about side effects.

community Androgen degraders for hair loss

61 upvotes 2 years ago

The conversation discusses androgen receptor degraders for hair loss, highlighting their potential advantages over traditional AR blockers like RU58841 and pyrilutamide. Concerns about the safety and cost of these treatments are also mentioned.

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