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research Beyond Spectral Similarity: How to Distinguish Polymorphs with Similar Solid-State Circular Dichroism Anisotropy Spectra?

August 2025 in “ChemPhotoChem”

A new method using solid-state circular dichroism anisotropy can distinguish similar chiral compounds better than traditional techniques.

High-Resolution Structures of Mutants Affecting Access to the Ligand-Binding Cavity of Human Lipocalin-Type Prostaglandin D Synthase

research High-Resolution Structures of Mutants Affecting Access to the Ligand-Binding Cavity of Human Lipocalin-Type Prostaglandin D Synthase

5 citations , July 2014 in “Acta Crystallographica Section D-biological Crystallography”

Mutations in the enzyme don't significantly change how it binds to its specific substances.

The Binding of Small Molecules and Polymers to Keratin and Their Effects on the Physicochemical and Surface Properties of Hair Fibers

research The Binding of Small Molecules and Polymers to Keratin and Their Effects on the Physicochemical and Surface Properties of Hair Fibers

7 citations , January 1981 in “Springer eBooks”

Certain small molecules and polymers can change hair's physical properties and how it feels by affecting the bonds within the hair.

research In Silico Structural Prediction of Human Steroid 5α-Reductase Type II

3 citations , March 2016 in “Medicinal Chemistry Research”

Scientists found out the structure of a human enzyme linked to prostate cancer and hair loss, which could help in designing drugs.

research Pharmacophore Modeling and Three Dimensional Database Searching for Drug Design Using Catalyst: Recent Advances

153 citations , November 2004 in “Current Medicinal Chemistry”

The document concludes that Catalyst software is effective for drug design, identifying potent compounds for various medical conditions.

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community Say this new supposed miracle drug “PP405” does actually cure baldness, how will that affect people with hair transplants?

in Chat 200 upvotes 8 months ago

PP405 may reactivate dormant hair follicles but won't replace hair transplants or resurrect dead follicles. Its effectiveness, cost, and impact compared to treatments like minoxidil and finasteride are uncertain.

community If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

nkrata in Research 830 upvotes 1 year ago

Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

community Topical finasteride now the safest possible path?

in Finasteride/Dutasteride 84 upvotes 1 year ago

Topical finasteride is considered a safer option for hair regrowth with fewer systemic side effects compared to oral finasteride. Some users report similar efficacy and side effects between topical and oral treatments, while others prefer topical due to reduced systemic exposure.

community My Theory Regarding a Cause and Cure for Androgenetic Alopecia

in Treatment 99 upvotes 6 years ago

Hair loss theory suggests imbalance between Vitamin D Receptor (VDR) and Androgen Receptor (AR) activation. Proposed treatment includes upregulating VDR, downregulating AR, and improving mitochondrial health.

community Oral minoxidil is not good for your health, let’s use research chemicals bought from AliExpress

in Satire 551 upvotes 3 years ago

. This conversation discussed the efficacy of Minoxidil and Finasteride as treatments for hair loss, with a focus on the potential side effects of taking Oral Minoxidil. Some users shared their experiences with both treatments and there was debate over whether they were safe or not.

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