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This study found that polycaprolactone gel injections were significantly more effective than sodium hyaluronate gel in improving nasolabial fold severity for Chinese patients over 12 months, with similar rates of mild injection-related adverse events between the groups.

This study reported that a novel filler, BM-PHA, demonstrated similar efficacy and safety to Restylane Perlane in treating moderate to severe nasolabial folds over 24 weeks, showing only minor local side effects and similar improvements in wrinkle severity scores between the two treatments.

This study observed that using ultra-high-frequency ultrasound with 70 MHz probes effectively assessed the distribution of hyaluronic acid fillers and improvements in nasolabial fold wrinkles, with significant changes in dermal thickness and wrinkle scores maintained 24 weeks after treatment.

This study found that participant self-assessments suggested greater improvement in the texture and wrinkles of facial skin treated with PRP compared to normal saline, though dermatologist ratings showed no significant difference.

In this study, Juvéderm repeat treatments maintained wrinkle correction in nasolabial folds for up to 21 months and required significantly less filler than the initial treatment, indicating potential benefits for patients.