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research Is Wnt5a overexpression sufficient for generating a psoriasis‐like phenotype in transgenic mice?

2 citations , December 2014 in “Experimental Dermatology”

In this study, overexpression of Wnt5a in transgenic mice did not produce psoriasis-like skin changes but affected hair follicle cycling, suggesting its potential relevance to hair disorders rather than psoriasis.

research Expression of Wnt Genes in Echinaster Sepositus Arm Regeneration

2 citations , January 2018 in “International Journal of Biochemistry & Physiology”

This study identified two new Wnt genes, EsWnt1 and EsWnt4, in red starfish, with their expression patterns suggesting a role in wound healing and regeneration.

research Effect of the FA2H Gene on cashmere fineness of Jiangnan cashmere goats based on transcriptome sequencing

17 citations , July 2022 in “BMC Genomics”

This study found that overexpression of the FA2H gene in cashmere goats' hair follicle cells may enhance hair proliferation and regulate genes affecting cashmere fineness.

Wnt/β-Catenin Signaling: Function, Biological Mechanisms, and Therapeutic Opportunities

research Wnt/β-catenin signalling: function, biological mechanisms, and therapeutic opportunities

318 citations , January 2022 in “Signal Transduction and Targeted Therapy”

This study systematically reviews the Wnt/β-catenin signaling pathway, discussing its origin, composition, function, involvement in tumors and diseases, and the development of small-molecular compounds targeting this pathway for disease treatment.

research Identification of key pathways and genes that regulate cashmere development in cashmere goats mediated by exogenous melatonin

3 citations , September 2022 in “Frontiers in veterinary science”

This study identified key genes and signaling pathways involved in cashmere goat hair follicle growth cycles, influenced by melatonin implantation, suggesting a basis for further research on melatonin's regulatory mechanism.

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community My understanding of how androgenetic alopecia works (plus FIN and DUT)

18 upvotes 4 years ago

Androgenetic alopecia is affected by scalp DHT levels, not sensitivity, with treatments like finasteride and dutasteride aiming to optimize these levels. Personalized DHT management is crucial for effective hair growth.

community Better Than Minoxidil? Topical Sodium Valproate

50 upvotes 1 year ago

Topical sodium valproate may promote hair growth by inhibiting GSK3β, allowing beta-catenin to proliferate, but it has potential side effects and requires more research. The conversation also mentions skepticism about a product called Vdphlo1, which includes sodium valproate and other ingredients.

community Scalp testosterone does NOT cause hair loss, what is this baseless claim ?

in Research/Science 13 upvotes 5 months ago

DHT, not testosterone, causes hair loss. Treatments like finasteride, dutasteride, and RU58841 target DHT to manage hair loss.

community A Theory on Why Microneedling Works

175 upvotes 6 years ago

Microneedling may enhance hair regrowth by transferring stem cells to dormant follicles, improving the effects of minoxidil. Users discuss using microneedling with needle lengths around 1.5mm to stimulate hair growth.

community Do you keep gains if you stop microneedling?

in Microneedling 15 upvotes 1 year ago

Stopping microneedling may result in losing hair gains, as it enhances the effectiveness of treatments like minoxidil. Combining microneedling with minoxidil and finasteride is more effective than using microneedling alone.

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Hair System Specialist
Jane Genesi
Marlton, PA, United States

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Jane Genesi