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Faculty Opinions Recommendation of Hair Regrowth Following a Wnt- and Follistatin-Containing Treatment: Safety and Efficacy in a First-in-Man Phase 1 Clinical Trial

research Faculty Opinions recommendation of Hair regrowth following a Wnt- and follistatin containing treatment: safety and efficacy in a first-in-man phase 1 clinical trial.

July 2012 in “Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature”

New treatment with Wnt proteins and growth factors safely increases hair thickness.

research Hair regrowth following a Wnt- and follistatin containing treatment: safety and efficacy in a first-in-man phase 1 clinical trial.

16 citations , November 2011 in “PubMed”

This study found that a single intradermal injection of Hair Stimulating Complex significantly improved hair growth in men with androgenetic alopecia compared to placebo.

research Characterization and isolation of stem cell–enriched human hair follicle bulge cells

January 2007 in “The Year book of dermatology”

Researchers successfully isolated and identified key stem cells in human hair follicles, which could help develop new skin and hair treatments.

Androgenetic Alopecia: Combing the Hair Follicle Signaling Pathways for New Therapeutic Targets and More Effective Treatment Options

research Androgenetic alopecia: combing the hair follicle signaling pathways for new therapeutic targets and more effective treatment options

19 citations , August 2019 in “Expert Opinion on Therapeutic Targets”

This review discusses emerging targets for developing drugs to treat hair loss and reports no new clinical results; the authors emphasize the potential for therapies that regenerate hair follicles.

research Cell-based treatments for hair loss: research update on “hair cloning”

2 citations , March 2013 in “Hair transplant forum international”

This article discusses the concept of hair cloning through cultured follicular cell implantation but provides no new experimental results; it highlights ongoing interest among hair restoration professionals and the public.

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community Hair Regrowth Following a Wnt- and Follistatin- Containing Treatment: Safety and Efficacy in a First-in-Man Phase 1 Clinical Trial: Scientific, Peer-Reviewed Dermatology Article Indexed with MEDLINE/PubMed

4 upvotes 12 years ago

A treatment containing Wnt and Follistatin was found to be safe and effective for hair regrowth in a Phase 1 clinical trial. Specific treatments discussed include Minoxidil, Finasteride, and RU58841.

community 30-Min Dermatology Visit – Best Questions to Ask About Balding? ( 175$ )

6 upvotes 1 year ago

The conversation discusses hair loss treatments, focusing on finasteride, minoxidil, and other options like PRP and ketoconazole. It highlights the importance of asking specific questions during a dermatology visit to determine the cause of hair loss and appropriate treatments.

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learn Follistatin

glycoprotein that inhibits TGF-β and promotes hair growth by antagonizing activin

Are there any clinical studies supporting follistatin as a hair loss treatment? There is no controlled human trial showing follistatin treats hair loss; the published work is mouse and laboratory biology on the activin/follistatin signalling system, plus one small 2011 phase 1 injection study of a combination product, so follistatin remains experimental and unapproved.
What is follistatin, and how does it influence hair follicle growth and regeneration? Follistatin blocks activin and related growth-inhibiting proteins, which in laboratory and animal work is described as keeping hair follicles in their growth phase; the only verifiable human evidence is a single small 2011 phase 1 injection trial, so follistatin remains experimental and is not an approved hair-loss treatment.
Is follistatin safe for use in women or transgender individuals undergoing hormone therapy? No study has tested follistatin in women or transgender people on hormone therapy, and it has no approved human use or established dose; the one relevant signal, from a 2023 randomized study in adolescents with PCOS, links higher follistatin to less favourable metabolic markers, so the published evidence does not support using it in this group.
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