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Sensitive Quantitative In Vivo Assay for Evaluating the Effects of Biomolecules on Hair Growth and Coloring Using Direct Microinjections into Mouse Whisker Follicles

research Sensitive Quantitative In Vivo Assay for Evaluating the Effects of Biomolecules on Hair Growth and Coloring Using Direct Microinjections into Mouse Whisker Follicles

July 2023 in “Biomolecules”

The new "whisker follicle microinjection assay" can test how different biomolecules affect hair growth and color.

research Increased Vibrissa Growth in Transgenic Mice Expressing Insulin-Like Growth Factor 1

33 citations, February 1999 in “The journal of investigative dermatology/Journal of investigative dermatology”

IGF-1 increases whisker growth in transgenic mice.

research Targeting Wnt/β-Catenin Pathway for Developing Therapies for Hair Loss

86 citations, July 2020 in “International Journal of Molecular Sciences”

Activating the Wnt/β-catenin pathway could lead to new hair loss treatments.

research Transcriptome Analysis of Improved Wool Production in Skin-Specific Transgenic Sheep Overexpressing Ovine β-Catenin

4 citations, January 2019 in “International journal of molecular sciences”

Genetically modified sheep with more β-catenin grew more wool without changing the wool's length or thickness.

research Homozygous Whole Body Cbs Knockout in Adult Mice Features Minimal Pathology During Aging Despite Severe Homocysteinemia

7 citations, March 2022 in “The FASEB journal”

Adult mice with CBS deficiency show minimal health issues and normal lifespan despite high homocysteine levels.

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Community Join

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community Seems I have acquired progressive kinking of the hair, potentially brought on by minox.

11 upvotes 7 years ago

User experienced hair kinking after starting minoxidil, despite being on finasteride for two years. Another user confirmed similar issues and suggested switching brands due to propylene glycol in minoxidil.

community Just quit nicotine and caffeine

in Treatment 20 upvotes 3 years ago

The user has been using finasteride and oral minoxidil for hair loss but hasn't seen improvement and is quitting nicotine and caffeine to see if it helps. Some believe quitting nicotine improved their hair health due to better blood flow, while others are skeptical about the impact of blood flow on hair loss.

community Guys… Pelage might just be the one. They might actually find the cure. I work in tech - let me explain.

in Technology 187 upvotes 1 month ago

Pelage, backed by Google Ventures, is seen as a promising company potentially finding a cure for hair loss using stem cell activation. There is skepticism and optimism among users, with some awaiting results from ongoing trials.

community Anyone else growing tired of the finasteride wars?

in Finasteride/Dutasteride 169 upvotes 1 year ago

The conversation is about differing experiences with finasteride for hair loss, with some users reporting side effects and others not, and the debate over the drug's safety and effectiveness. Specific treatments mentioned include finasteride, dutasteride, and topical finasteride.

community 1 years progress. Thoughts please?

in Is this regrowth? 57 upvotes 4 days ago

The user is using topical minoxidil and oral finasteride for hair regrowth, with plans for a future hair transplant. They are considering additional treatments like dermastamping and exploring options for dutasteride, which is unavailable in their country.

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