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GlossaryWax Esters

long-chain fatty acid and alcohol compounds in sebum

Wax esters are long-chain fatty acid and long-chain alcohol compounds that are found in various natural sources, including the sebum produced by human skin. They play a crucial role in providing a protective barrier, helping to retain moisture and protect against environmental damage. In the context of hair, wax esters contribute to the natural shine and manageability of hair by coating the hair shaft and reducing friction.

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Preparation of 4-Aryl-2-Trifluoromethylbenzonitrile Derivatives as Androgen Receptor Antagonists for Topical Suppression of Sebum Production

research Preparation of 4-Aryl-2-Trifluoromethylbenzonitrile Derivatives as Androgen Receptor Antagonists for Topical Suppression of Sebum Production

11 citations , August 2007 in “Bioorganic & Medicinal Chemistry Letters”

Scientists made a chemical (compound 4e) that can be applied on skin to reduce oil production, which can help with acne, but it might cause skin sensitivity to light.

Rational Design of a Topical Androgen Receptor Antagonist for the Suppression of Sebum Production with Properties Suitable for Follicular Delivery

research Rational Design of a Topical Androgen Receptor Antagonist for the Suppression of Sebum Production with Properties Suitable for Follicular Delivery

11 citations , May 2010 in “Journal of Medicinal Chemistry”

A new compound was created in 2010 that can control oil production when applied to the skin, and its effects are completely reversible after two weeks.

research Convergent Decay of Skin-Specific Gene Modules in Pangolins

1 citations , December 2022 in “bioRxiv (Cold Spring Harbor Laboratory)”

Pangolins have lost some skin-related genes, but kept others, showing complex skin evolution.

research Sebaceous Gland Abnormalities in Fatty Acyl CoA Reductase 2 (Far2) Null Mice Result in Follicular Dystrophy and Primary Cicatricial Alopecia

April 2018 in “Journal of Investigative Dermatology”

Mutations in Far2 mice cause hair loss due to sebaceous gland issues.

research Sdr16c5 and Sdr16c6 Control a Dormant Pathway at a Bifurcation Point Between Meibogenesis and Sebogenesis

June 2023 in “Journal of biological chemistry/The Journal of biological chemistry”

Sdr16c5 and Sdr16c6 genes regulate a key point in lipid production that affects eye and skin gland function.

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community If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

nkrata in Research 830 upvotes 1 year ago

Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

community 4 years; fin 1mg/day @ 4 years; minox twice daily @ 3 years; estradiol 5mg/day @ 3 months; spiro 100 mg /day @ 3 months (Wet hair because it's easy to hide issues with dry hair)

in Progress Pictures 198 upvotes 1 year ago

The user shared their 4-year hair regrowth progress using finasteride, minoxidil, estradiol, and spironolactone. They noted significant regrowth by the second year and additional benefits from estradiol and spironolactone.

community I hate how my hair loss changed me.

in Chat 169 upvotes 5 years ago

A man's experience with hair loss, which has caused him to lose an important part of his identity, and the treatments he is using to try and combat it. Others have joined in the conversation to share their own experiences and offer support.

community I'm already DOING EVERYTHING!!!

in Female 26 upvotes 5 years ago

A 26 year old female dealing with hair loss who is considering treatments such as Spiro, minoxidil and finasteride. Other potential solutions mentioned are PRP treatment, a wig, and bio-identical estrogen combined with bica.

community 1.4 years on finasteride, only lately have signs of improvement been showing

in Progress Pictures 232 upvotes 1 year ago

The user noticed hair density improvement after 1.4 years on finasteride, with additional use of minoxidil on the temples. Other users discussed various treatments like dutasteride, estrogen, and hair transplants, sharing personal experiences and advice.

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