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research Role of Lipids in Water Permeation of Different Curl Pattern Hair Types

September 2025 in “Cosmetics”

In this study, researchers found that the lipid composition in hair significantly affects water diffusion and may explain differences in dyeing and cosmetic treatment responses between Asian and European hair, with CP2 fibers having more lipids than CP3 fibers.

research Kinetics and Equilibrium of Solute Diffusion into Human Hair

8 citations , July 2012 in “Annals of biomedical engineering”

This study found that the uptake of molecules by hair is influenced by both hydrophobic and ionic charge interactions, with binding affinity decreasing as pH approaches the solute's dissociation constant.

research In vitro and in vivo study of dye diffusion into the human skin and hair follicles

69 citations , January 2002 in “Journal of biomedical optics”

This study found that commercially available dyes penetrate up to 1.2 mm into human skin, with Indocyanine Green binding to cell proteins and showing a shift in absorption peak.

research Determination of Solute Diffusion Properties in Artificial Sebum

6 citations , May 2019 in “Journal of pharmaceutical sciences”

This study found that diffusion coefficients of chemicals in artificial sebum are significantly higher than those in stratum corneum lipids, suggesting the hair follicle may significantly contribute to transdermal permeation.

research Exogenous and endogenous lipids of human hair

21 citations , March 2017 in “Skin research and technology”

In this study, extracting internal lipids from Caucasian hair fibers led to decreased water permeability, influenced by the fluidity of lipids.

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community Minoxidil Skin Delivery from Nanoemulsion Formulations Containing Eucalyptol or Oleic Acid: Enhanced Diffusivity and Follicular Targeting

4 upvotes 1 year ago

Minoxidil can be effectively delivered through nanoemulsions containing eucalyptol or oleic acid, enhancing its diffusivity and targeting hair follicles. This contradicts the advice against mixing minoxidil with oils in topical formulations.

community Why you can still look forward to PP405 and JXL-069

22 upvotes 1 month ago

PP405 and JXL-069 are the same compound, but users experienced no results due to flawed application methods. The topical gel formulation of PP405 is designed to target hair follicle stem cells effectively, unlike liquid solutions that fail to penetrate deeply.

community Has anyone regrown hair after iron/zinc deficiency?

30 upvotes 5 years ago

Hair regrowth after addressing iron/zinc deficiency. Treatments mentioned include daily supplements of iron and zinc.

community Progress over 3 years of thinning

216 upvotes 6 months ago

The user experienced significant hair regrowth over three years using a combination of dutasteride, oral minoxidil, dermarolling, and Nizoral shampoo. Initial side effects from finasteride subsided after switching to dutasteride, leading to improved hair density and thickness.

community can we talk about the effect of DHT on hair TEXTURE (not just thickness/density)

41 upvotes 1 month ago

Finasteride treatment improved hair texture and reduced frizz for some users, though full restoration of original texture may take time. Hair texture changes were noted across the head, with some areas responding faster to treatment.

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learn Rice Water

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