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research Chloroquine and Cinchonine Affect Rat Vascular Smooth Muscle Tonus Through Calcium Channels – In Silico and In Vitro Approaches

January 2024 in “Bratislavské lekárske listy/Bratislava medical journal”

Chloroquine and cinchonine relax rat blood vessels by affecting calcium channels, with chloroquine needing caution in heart patients.

research Root Hair Growth in Arabidopsis Thaliana Is Directed by Calcium and an Endogenous Polarity

200 citations , November 1997 in “Planta”

Calcium affects where root hairs grow, but other unknown factors determine their growth direction.

Skin Morphogenesis by Coupling Biochemical-Bioelectric Signals: Calcium Oscillations Coordinate Dermal Cell Movement by Epidermis-Derived SHH Signaling During Feather Bud Orientation

research Skin Morphogenesis by Coupling Biochemical-Bioelectric Signals: Calcium Oscillations Coordinate Dermal Cell Movement by Epidermis-Derived SHH Signaling During Feather Bud Orientation

April 2019 in “Journal of Investigative Dermatology”

Calcium signals and SHH guide the direction of feather growth in chicken skin.

research The Incidental Pore: CaV1.2 and Stem Cell Activation in Quiescent Hair Follicles

3 citations , June 2013 in “Genes & development”

CaV1.2 helps activate hair follicle stem cells without calcium flux.

research Anti-Invasive Effects of Minoxidil on Human Breast Cancer Cells: Combination with Ranolazine

5 citations , May 2022 in “Clinical & Experimental Metastasis”

Minoxidil and ranolazine together can reduce the spread of certain breast cancer cells.

View more "voltage-gated ca2 channels" in research →

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community Hairline stable but diffuse thinning with topical fin+min

in Finasteride 237 upvotes 1 month ago

The user experienced stable hairline but diffuse thinning after switching from oral finasteride to a topical solution of minoxidil and finasteride. They are concerned about the effectiveness of the topical treatment and are considering other options due to a recent decline in hair density.

community REVOLUTION in AUGUST: New possibilities according to Dr. Muñoz (pinacidil, cromakalim, diazoxide and nicorandil)

in Technology 13 upvotes 6 months ago

Dr. Muñoz's discovery suggests that targeting potassium channels in fibroblasts could reactivate hair growth, offering new treatment possibilities for alopecia. Potential strategies include using minoxidil, diazoxide, and other potassium channel openers, as well as bioelectric devices and direct growth factor applications.

community PP405 Won’t Work: Follicle Is Miniaturized, Fibrosed, And Missing Key Support Cells

in Research/Science 1 month ago

PP405 is ineffective for miniaturized, fibrosed hair follicles in androgenetic alopecia. AMP303 may activate hair follicle stem cells, but minoxidil and finasteride are still the main treatments.

community Got my Oleic fatty acid they used in Korean study. Fuck you mice!

in Research/Science 244 upvotes 2 months ago

Oleic acid and microneedling are being explored for hair regrowth, but results are mixed. Addressing DHT and fibrosis is crucial, with treatments like finasteride, minoxidil, and scalp massage also discussed.