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research Topical Rice Bran Oil (Oryza sativa L.) Has The Same Effect With 2% Topical Minoxidil To Prevent Senile Alopecia Through Improved Vascular Endothelial Growth Factor (VEGF) Protein Expression, Hair Follicle Diameter And Length In Wistar Rats (Rattus norvegicus) Exposed To Ultraviolet B Light

January 2023 in “International journal of research publications”

According to this study, rice bran oil was as effective as 2% minoxidil in improving hair growth parameters, such as VEGF expression, follicle diameter, and hair length, in Wistar rats treated for 21 days, showing potential for preventing hair thinning associated with aging.

research Serenoa repens and N‐acetyl glucosamine/milk proteins complex differentially affect the paracrine communication between endothelial and follicle dermal papilla cells

3 citations , November 2018 in “Journal of cellular physiology”

In laboratory settings, this study suggests that Serenoa repens and N-acetyl glucosamine with milk proteins may promote hair follicle vascularization through specific cellular interactions and actions.

research Insights from Tandem Mass Tag (TMT) Proteomic Analysis on Protein Network Modification in Control of Yak Hair Follicle Cycle

2 citations , February 2025 in “International Journal of Molecular Sciences”

This study identified key proteins, such as Sfrp1 and Ppard, involved in the complex and dynamic regulation of yak hair follicle growth and degeneration across different stages, offering insights into yaks' adaptation to highland environments.

research Effects of latanoprost on vascular endothelial growth factor protein synthesis in human dermal papilla cells

January 2006

In this study, latanoprost was found to stimulate VEGF protein synthesis in human dermal papilla cells, suggesting it may contribute to promoting hair growth.

research VEGF upregulates VEGF receptor-2 on human outer root sheath cells and stimulates proliferation through ERK pathway

23 citations , June 2012 in “Molecular Biology Reports”

This study found that human outer root sheath cells express VEGF receptor-2, and exogenous VEGF165 significantly stimulates their proliferation through activation of the ERK signaling pathway.

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learn Follistatin

Protein that blocks activin, a growth-regulating signal

learn Epidermal Growth Factor

learn Vascular Endothelial Growth Factor

Is Vascular Endothelial Growth Factor (VEGF) available as a topical treatment, or is it only stimulated indirectly? VEGF is not available as a topical treatment for hair loss.
How does Vascular Endothelial Growth Factor (VEGF) differ from DHT-blocking treatments for androgenic alopecia? VEGF promotes blood vessel growth, while DHT-blocking treatments reduce hormone effects on hair follicles.
Are there risks or side effects associated with treatments that increase Vascular Endothelial Growth Factor (VEGF)? In a VEGF gene-therapy trial for leg artery disease, raising VEGF caused more leg swelling, and excess VEGF drives leaky, abnormal vessels in mice and in eye disease. No long-term studies have tested the safety of treatments that raise VEGF in the scalp.
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community Short Peptides for Hair Loss: anyone tried any of these?

14 upvotes 5 months ago

Various peptides are discussed for treating male pattern baldness, with some available for topical use like GHK-Cu and Ac-KGHK, while others remain in research stages. Users are interested in experiences and sourcing these treatments.

community IGF-1 and Peptides? Miracle molecule waiting to be found

10 upvotes 1 year ago

The conversation discusses potential hair loss treatments focusing on stimulating IGF-1 at the follicle level using growth-factor cocktails and engineered peptides, such as Acetyl Tetrapeptide-3, Copper Tripeptide-1, Oligopeptide-20, Thymosin-β4, and Palmitoyl Tetrapeptide-7. It suggests that device-assisted delivery methods like microneedling may enhance effectiveness.

community Surprisingly thorough study on He-Shou-Wu/Fo Ti

13 upvotes 3 years ago

He Shou Wu (Fo Ti) extract was found to prolong the hair growth phase, inhibit 5-alpha-reductase (like finasteride), reduce androgen receptors, and increase growth factors, potentially outperforming minoxidil in recovering hair follicle size after DHT exposure. Two compounds, emodin and TSG, are identified as responsible for these effects and warrant further investigation.

community What About Phytosterol Alternatives - Rice Bran Oil - Natural DHT Blockers

3 upvotes 2 years ago

The conversation discusses natural DHT blockers like rice bran oil, which may reduce 5α-reductase activity similarly to Minoxidil and Dutasteride. One user argues that finasteride is more reliable and effective than natural alternatives.

community Aminexil - is it possible that if you stop using it you lose more hair than you had originally?

1 upvotes 1 year ago

Aminexil is used to strengthen hair roots but stopping it may lead to hair thinning, unlike minoxidil which has more complex effects. The user did not use finasteride or minoxidil due to concerns about side effects.

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