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research In vivo function of VDR in gene expression-VDR knock-out mice

73 citations , April 1999 in “Journal of steroid biochemistry and molecular biology/The Journal of steroid biochemistry and molecular biology”

This study found that the vitamin D-VDR system is crucial for mineral and bone metabolism post-weaning and identified missense mutations in 1alpha-hydroxylase causing type I rickets.

research Novel mechanisms for the vitamin D receptor (VDR) in the skin and in skin cancer

71 citations , October 2014 in “The Journal of Steroid Biochemistry and Molecular Biology”

This study highlights the complex role of the vitamin D receptor in skin processes, where its disruption, along with calcium and co-regulator imbalances, could contribute to skin cancer development by altering skin differentiation and hair follicle cycling.

Disruption of the Hedgehog Signaling Pathway Contributes to Hair Follicle Cycling Deficiency in VDR Knockout Mice

research Disruption of the hedgehog signaling pathway contributes to the hair follicle cycling deficiency in Vdr knockout mice

53 citations , May 2010 in “Journal of Cellular Physiology”

This study found that mice lacking the Vitamin D receptor showed disrupted hair follicle cycling, which was partially restored with hedgehog signaling pathway activation, suggesting a role for this pathway in follicle regulation independent of vitamin D.

research 1α,25(OH)2-Dihydroxyvitamin D3/VDR protects the skin from UVB-induced tumor formation by interacting with the β-catenin pathway

45 citations , September 2012 in “The Journal of Steroid Biochemistry and Molecular Biology”

This study found that deleting β-catenin in epidermis-specific VDR knockout mice did not prevent UVB-induced skin tumors, indicating β-catenin does not compensate for VDR's role in tumor suppression.

Analysis of 1,25-Dihydroxyvitamin D3 Receptors in Basal Cell Carcinomas

research Analysis of 1,25-Dihydroxyvitamin D3 Receptors (VDR. in Basal Cell Carcinomas

42 citations , August 1999 in “The American journal of pathology”

This study found that basal cell carcinomas show strong expression of vitamin D receptors at both mRNA and protein levels, suggesting a potential role in tumor growth regulation.

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community Are You Hopeful About VDPHL01?

17 upvotes 1 month ago

VDPHL01 is seen as a promising hair loss treatment, especially for those who can't use minoxidil due to side effects like chest pain and dizziness. Users discuss the potential benefits of combining VDPHL01 with hair transplants and express hope for fewer side effects compared to existing treatments like finasteride and dutasteride.

community VDPHL01 phase-2/3 results comparison

in Research/Science 128 upvotes 4 months ago

The conversation discusses hair loss treatments, focusing on a new slow-release oral minoxidil compared to topical minoxidil and finasteride. The results show that twice-daily dosing of the new treatment is slightly more effective than once-daily, but concerns about cost, side effects, and the accuracy of reported results remain.

community VDPHL01 works really quickly .. apparently?

50 upvotes 5 months ago

VDPHL01 shows faster and stronger hair growth compared to standard minoxidil, with no major side effects reported. Users discuss combining it with other treatments like dutasteride and finasteride for better results, while expressing skepticism about the effectiveness of PP405.

community VDPHL01 - could it be the replacement to DHT blockers?

8 upvotes 5 months ago

VDPHL01 is discussed as a potential replacement for DHT blockers, with comparisons to minoxidil. Users express skepticism about its effectiveness without addressing DHT, suggesting it may only slow hair loss rather than stop it.

community VDPHL-01 is Overrated and Ridiculous. This is just Oral Minoxidil.

in Research/Science 21 upvotes 1 year ago

VDPHL-01 is essentially a slow-release oral minoxidil, which is already known to work for hair growth. The formulation includes other ingredients like Medrogestone, Valproic acid, Setipiprant, and Cetirizine, but their effectiveness and necessity are questioned.

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Jessica vd Es
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