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Minoxidil Improves Vascular Compliance, Restores Cerebral Blood Flow, and Alters Extracellular Matrix Gene Expression in a Model of Chronic Vascular Stiffness

research Minoxidil improves vascular compliance, restores cerebral blood flow, and alters extracellular matrix gene expression in a model of chronic vascular stiffness

34 citations , July 2018 in “American Journal of Physiology-heart and Circulatory Physiology”

Minoxidil improves blood flow and vessel flexibility, potentially helping with vascular stiffness.

research Androgenetic alopecia is associated with increased arterial stiffness in asymptomatic young adults

14 citations , March 2014 in “Journal of The European Academy of Dermatology and Venereology”

This study found that androgenetic alopecia in asymptomatic young men was associated with increased arterial stiffness, as measured by the cardio-ankle vascular index.

research Dihydrotestosterone induces arterial stiffening in female mice

January 2024 in “Biology of sex differences”

This animal study observed that dihydrotestosterone increased arterial stiffness and decreased estrogen receptor expression in female mice, potentially impacting cardiovascular health in contexts of androgen use.

research Scalp Analysis with Multiparametric Ultrasound before and after Application of Cosmetic with Vasoconstrictor Active

February 2025 in “Brazilian Journal of Hair Health”

This study found that multiparametric ultrasound effectively detects real-time scalp changes caused by vasoconstrictive cosmetic agents, demonstrating its potential as a non-invasive tool for evaluating trichological treatments.

research Dihydrotestosterone Induces Arterial Stiffening in Female Mice

February 2023 in “Research Square (Research Square)”

This study found that testosterone contributed to increased arterial stiffness and cardiovascular damage in female mice, linked with decreased estrogen receptor expression, and suggests implications for women with polycystic ovarian syndrome or those taking testosterone.

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community Efficacy of Dut at 0.5mg VS 1mg VS 2.5mg

in Finasteride/Dutasteride 49 upvotes 1 year ago

Higher doses of dutasteride, such as 2.5mg, are more effective at reducing scalp DHT than 0.5mg, but are costly and inconvenient. A 1mg dose is considered a more affordable and practical option, though its efficacy is uncertain.

community The Real Reason For Hair Loss?

8 months ago

Hair loss is linked to scalp fibrosis and tension, which result from chronic mechanical stress and androgenic signaling. Treatments include blocking androgens with finasteride, promoting hair growth with topical minoxidil, and improving scalp mobility through exercises.

community Hair loss research focused on chemistry for decades because we misunderstood the mechanics of growth.

51 upvotes 7 months ago

Hair growth relies on mechanical forces, not just chemicals, with tissue acting like a motor. Minoxidil and finasteride help, but maintaining tissue elasticity and addressing mechanical issues are essential.

community Occipitalis Muscle Tension Theory

13 upvotes 7 months ago

Scalp tension from the occipitalis muscle is theorized to contribute to hair loss, but most believe DHT and genetics are the main causes. Treatments like finasteride and minoxidil are considered more effective than addressing scalp tension.

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learn Vascular Endothelial Growth Factor

What is Vascular Endothelial Growth Factor (VEGF), and how does it support hair growth in alopecia? VEGF promotes hair growth by enhancing blood supply to hair follicles.
Can products that stimulate Vascular Endothelial Growth Factor (VEGF) improve blood flow to hair follicles? Yes, products that stimulate VEGF may improve blood flow to hair follicles.
Is Vascular Endothelial Growth Factor (VEGF) available as a topical treatment, or is it only stimulated indirectly? VEGF is not available as a topical treatment for hair loss.
All 5 questions on Vascular Endothelial Growth Factor →

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Clinics

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15
Hair Loss Treatments
VIVAA-Vein Vascular Primary Care & Aesthetic AssociatesIssaquah, WA · US

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