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GlossaryGray Hair (Unpigmented hair)

reduced melanin production in hair follicles causes color loss

Gray hair, also known as canities, occurs when the pigment-producing cells in hair follicles, called melanocytes, decrease their production of melanin. This reduction in melanin leads to hair strands losing their color and appearing gray or white. The process is often associated with aging but can also be influenced by genetic factors, stress, and certain medical conditions.

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research Towards A Free Radical Theory Of Graying: Melanocyte Apoptosis In The Aging Human Hair Follicle As An Indicator Of Oxidative Stress Induced Tissue Damage

210 citations , May 2006 in “The FASEB journal”

Oxidative stress causes hair to gray by damaging and killing pigment cells.

research Grey Hair: Clinical Investigation Into Changes in Hair Fibres With Loss of Pigmentation in a Photoprotected Population

17 citations , February 2011 in “International Journal of Cosmetic Science”

Grey hair is wilder, drier, and less manageable than pigmented hair.

research Premature Graying as a Consequence of Compromised Antioxidant Activity in Hair Bulb Melanocytes and Their Precursors

46 citations , April 2014 in “PLOS ONE”

Gray hair may be caused by lower antioxidant activity in hair cells.

research Extensive Hair-Shaft Elongation by Isolated Mouse Whisker Follicles in Very Long-Term Gelfoam Histoculture

5 citations , September 2015 in “PLoS ONE”

Gelfoam® histoculture supports long-term hair and nerve growth in mouse whisker follicles.

research Regenerating Hair Follicles

May 2007 in “Science's STKE”

Healing skin wounds in mice can create new hair follicles, and adjusting Wnt signaling could potentially reduce scarring and treat hair loss.

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community NW4 -> NW 2.5 (1yr progress) RU 8.5-9% ED and topical Dut .1% + RU 5% 1.5x a week. (+ caffeine redensyl scalp treatment ED)

in Progress Pictures 39 upvotes 2 years ago

The conversation discusses hair regrowth progress from Norwood scale 4 to 2.5 over a year using daily 8.5-9% RU58841, topical Dutasteride 0.1%, RU58841 5% 1.5 times a week, and daily caffeine redensyl scalp treatment.