January 2023 in “Open veterinary journal” Cow blood vessel cell secretions helped heal rat burn wounds and may treat burns and hair loss.
132 citations
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April 2021 in “Stem Cell Research & Therapy” The study demonstrated that human acellular amniotic membrane (hAAM) scaffolds incorporating exosomes from adipose-derived mesenchymal stem cells (ADSC-Exos) significantly promoted diabetic wound healing. In vitro, ADSC-Exos enhanced the proliferation and migration of human dermal fibroblasts and the proliferation and tube formation of human umbilical vein endothelial cells. In vivo, using a diabetic mouse skin wound model, the hAAM-Exos dressing accelerated wound healing by regulating inflammation, stimulating vascularization, and promoting extracellular matrix production. These findings suggested that exosome-incorporated hAAM scaffolds had great potential for future clinical applications in treating diabetic skin wounds.
23 citations
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November 2018 in “International Journal of Molecular Sciences” Deoxyshikonin helps wounds heal faster in diabetic mice.
22 citations
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April 2022 in “Stem cell research & therapy” Hair follicle-derived extracellular vesicles may help heal chronic wounds as effectively as those from adipose tissue.
16 citations
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December 2018 in “ACS Biomaterials Science & Engineering” The new patch made of cell matrix and a polymer improves wound healing and supports blood vessel growth.