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Phenotypic Heterogeneity in Human Genetic Diseases: Ultrasensitivity-Mediated Threshold Effects as a Unifying Molecular Mechanism

research Phenotypic Heterogeneity in Human Genetic Diseases: Ultrasensitivity-Mediated Threshold Effects as a Unifying Molecular Mechanism

July 2023 in “Journal of Biomedical Science”

Different people show different symptoms for genetic diseases because of how sensitive their bodies are to small changes in important factors.

research Analysis of Protein Interactions by Surface Plasmon Resonance

42 citations, September 2017 in “Advances in protein chemistry and structural biology”

Surface Plasmon Resonance is a useful tool for studying protein interactions and has potential for future technological advancements.

research Cloning of a Functional Vitamin D Receptor from the Lamprey, an Ancient Vertebrate Lacking a Calcified Skeleton and Teeth

104 citations, May 2003 in “Endocrinology”

Lampreys have a functional vitamin D receptor that may help detoxify harmful substances.

research Applications and Risks of Nanomaterials Used in Regenerative Medicine, Delivery Systems, Theranostics, and Therapy

28 citations, January 2017 in “Critical Reviews in Therapeutic Drug Carrier Systems”

Nanomaterials in biomedicine can improve treatments but may have risks like toxicity, needing more safety research.

research The Androgen Receptor and Its Use in Biological Assays: Looking Toward Effect-Based Testing and Its Applications

22 citations, November 2011 in “Journal of Analytical Toxicology”

Scientists have developed a new method to detect steroid abuse in athletes using cell-based tests, which could be the future of anti-doping methods.

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Community Join

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community Nandrolone Replacement Therapy

in Treatment 41 upvotes 2 years ago

A user discusses starting nandrolone replacement therapy to stop hair loss and improve hair health, noting its benefits over finasteride. They report halted hair loss, improved skin, increased muscle, and a calm mood after three weeks.

community I’ve read multiple times that Fin increases hair quality… NOT for me!

in Treatment 97 upvotes 1 year ago

A user has been on finasteride for 6 months and feels their hair quality has worsened, experiencing more hair loss and scalp irritation. They are considering seeing a dermatologist, while others suggest the issue might be unrelated to finasteride, possibly due to deficiencies or other conditions.

community My Testosterone results before and after Finasteride

in Update 149 upvotes 3 years ago

Finasteride significantly increased testosterone levels for the user, with no major side effects except watery semen, which was resolved with zinc supplements. The user's hairline stopped receding and slightly improved.

community Did these tests—any of these linked to diffuse thinning?

in Research/Science 4 upvotes 3 months ago

A 25-year-old male experiencing diffuse thinning is advised to address high TSH levels and low iron, and consider treatments like finasteride. Weight loss and improved diet are also suggested to potentially help with hair health.

community A rare case? Or a blind spot? Hair loss caused by low T + e2

in Chat 7 upvotes 3 weeks ago

Low testosterone and estradiol may contribute to hair loss, and blocking DHT without sufficient hormone levels might hinder regrowth. The discussion highlights the importance of hormone balance, with some considering supplements and lifestyle changes to support hair health.

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