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GlossaryTyrosinase-Related Protein 1 (TRP1)

enzyme involved in melanin production affecting skin and hair color

Tyrosinase-Related Protein 1 (TRP-1) is an enzyme involved in the production of melanin, the pigment responsible for the color of skin, hair, and eyes. It plays a crucial role in the melanin synthesis pathway by stabilizing tyrosinase, another key enzyme, and influencing the type and amount of melanin produced, which can affect pigmentation and conditions like albinism and vitiligo.

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research Location and Fine Structure of Melanocytes in Human Fetal Scalp Hair Follicles

March 2009 in “Chinese Journal of Dermatology”

Melanocytes in the outer root sheath are likely stem cells that grow fast but stay immature.

research A TP63 Mutation Causes Prominent Alopecia with Mild Ectodermal Dysplasia

2 citations, May 2020 in “The journal of investigative dermatology/Journal of investigative dermatology”

A TP63 gene mutation causes significant hair loss and mild skin, nail, and tooth abnormalities.

research Regeneration of Mouse Skin Melanocyte Stem Cells In Vivo and In Vitro

1 citations, January 2018 in “Methods in molecular biology”

The research found ways to activate melanocyte stem cells for potential treatment of skin depigmentation conditions.

research Viewpoint 3

February 2008 in “Experimental dermatology”

Oxidative stress plays a significant role in vitiligo, and both skin and non-skin cells may be involved.

research Vitiligo: A Comprehensive Overview

532 citations, August 2011 in “Journal of the American Academy of Dermatology”

Vitiligo is a skin condition causing white spots, more common in women, often starts before age 20, and can affect mental health.

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