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research Treatment of Severe Alopecia Areata: Combination Therapy Using Systemic Cyclosporine A with Low Dose Corticosteroids

8 citations , January 2008 in “Annals of Dermatology”

This study concluded that combining systemic cyclosporine A with low-dose corticosteroids effectively treats severe alopecia areata while maintaining safe cyclosporine A levels in the blood.

research A Portable Electrospinner for Nanofiber Synthesis and Its Application for Cosmetic Treatment of Alopecia

20 citations , September 2019 in “Nanomaterials”

This study developed a portable electrospinning device that mimics hair for cosmetic thickening in a mouse model, showing performance comparable to benchtop models with added safety and cost benefits.

research A review of diagnosis and treatment of acne in adult female patients

116 citations , December 2017 in “International Journal of Women's Dermatology”

This review discusses various treatment options for adult female acne, highlighting the need for tailored approaches due to individual patient needs and reports no clinical outcomes.

research A multicentre placebo‐controlled clinical trial on the efficacy of oral ciclosporin A in the treatment of canine idiopathic sebaceous adenitis in comparison with conventional topical treatment

24 citations , May 2010 in “Veterinary dermatology”

This study found that both ciclosporin A and topical therapy were effective in reducing alopecia and scaling in dogs with idiopathic sebaceous adenitis, with evidence suggesting improved outcomes when both treatments are combined.

research Treatments for Moderate-to-Severe Alopecia Areata: A Systematic Narrative Review

1 citations , October 2023 in “Dermatology and therapy”

This review concluded that baricitinib and other oral JAK inhibitors have the most robust evidence supporting their use in treating severe alopecia areata in adults, compared to other less-evaluated treatments.

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community Pp405 AAD presentation tomorrow - fingers crossed - what to expect?

in Research/Science 84 upvotes 6 months ago

New hair loss treatments PP405 and VDPHL01 are discussed with skepticism and hope, alongside existing treatments like minoxidil and finasteride. Users express frustration over limited progress since the 1980s but remain cautiously optimistic.

community A Short Recap on PP405 and AAD 2026

in Update 5 months ago

PP405 is a promising experimental topical treatment for alopecia that reactivates dormant hair follicles by targeting cellular energy, with large-scale trials planned for 2026. While it shows potential, it cannot regenerate permanently destroyed follicles, making hair transplants the only guaranteed solution for advanced baldness currently.

community The expected timeline for PP405 - Next update at AAD Annual Meeting in March 2026 ?

34 upvotes 9 months ago

A new hair loss treatment, PP405, showed promising Phase 2a results with 31% of patients experiencing over 20% hair density increase without systemic absorption, avoiding hormonal side effects. The treatment is expected to be expensive, with Phase 3 trials starting mid-2026, and there is skepticism about the data's strength.

community Anyone Try Microneedling with Exosomes/AAPE?

2 upvotes 4 years ago

User asks where to purchase exosomes/AAPE for microneedling hair loss treatment. Links to research on hair regeneration therapy, stem cell therapy, exosome therapy, and dermal exosomes provided.

community Pelage PP405: New Hair Growth from Inactive Follicular Units - Phase 2a results at AAD 2026

1080 upvotes 6 months ago

PP405, a topical treatment, shows promise for hair growth by activating inactive follicles, with 66% of participants experiencing positive results. The treatment is well-tolerated and may proceed directly to Phase 3 trials, offering a potential alternative to minoxidil and finasteride.

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Learn

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learn Hair Transplant

What are the aftercare instructions following the hair transplant procedure? Follow your provider's aftercare instructions to ensure optimal healing and results.
What are the risks and side effects of a hair transplant? Reported risks include swelling, redness, folliculitis, numbness, infection, scarring and temporary shock loss; less often skin necrosis, poor graft growth or over-harvesting of the donor area.

learn Scalp Micropigmentation

Do I need time off work after my scalp micropigmentation? You typically don't need time off work after scalp micropigmentation.
Do I need to shave my head for scalp micropigmentation? Shaving your head is generally not required for scalp micropigmentation.
Are there any side effects of scalp micropigmentation? Short-term redness, swelling and itching are common. Less often, tattoo pigment causes allergic or granulomatous reactions, keloid scars, infection, blurring or colour change, sometimes years later.

learn Alopecia Areata

autoimmune disorder causing patchy hair loss

learn Tofacitinib

an immunosuppressant (JAK inhibitor) approved for arthritis and ulcerative colitis, used off-label for severe alopecia areata; it carries an FDA boxed warning

learn Baricitinib

Baricitinib is a JAK inhibitor FDA-approved in 2022 for adults with severe alopecia areata, where about a third of trial patients on 4 mg regained most scalp hair. It carries an FDA boxed warning, and hair loss usually returns when it is stopped.

learn Vitamin D

Low vitamin D is linked with some types of hair loss, especially alopecia areata, but there is no good evidence that supplements help hair unless you are deficient. Ask a doctor about a blood test before you supplement.

learn Neem Oil

Oil from the neem tree, used as a pesticide and in traditional remedies. Human evidence for hair or scalp benefits is limited; it can cause skin allergy and is poisonous if swallowed.

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