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This study systematically compared pediatric and adult Cushing's disease patients, revealing more severe and earlier-onset symptoms in males, and distinct gender-specific clinical manifestations.

This study found that older patients with Cushing's syndrome had fewer typical symptoms of hypercortisolism, more comorbidities, and were more often treated conservatively compared to younger patients.

This case study describes a 36-year-old woman with a history of recurrent limb weakness linked to hypokalemia and later diagnosed with Cushing syndrome indicated by elevated cortisol levels and a pituitary mass, which was treated with surgery and radiosurgery.

This case study highlights the importance of considering broad causes when evaluating hot flashes in middle-aged men, as it detailed a pituitary macroadenoma causing secondary hypogonadism in a man presenting with such symptoms.

This case study reports that in an 8-year-old male, a pituitary adenoma causing isolated high LH secretion led to early testosterone-driven puberty without typical testicular enlargement, highlighting the differential roles of LH and FSH in pubertal development.