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learn Valproic acid

Anti-seizure and mood-stabilising drug

How is valproic acid being explored differently in topical hair products compared to its traditional oral medical use? Topical valproic acid is being studied for local effects on the hair follicle rather than the whole-body effects of the oral drug. The human evidence is one small randomized 24-week trial of an 8.3% spray; no topical valproate product is approved for hair loss.
What is valproic acid, and how did it become a subject of interest in hair growth and alopecia research? Valproic acid is a prescription anticonvulsant that laboratory and mouse studies link to the Wnt/β-catenin hair-growth pathway; one small randomized trial of an 8.3% topical spray reported a hair-count gain over 24 weeks. Oral valproate is also a recognized cause of hair loss and a known teratogen.

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Research

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research Topical valproic acid increases the hair count in male patients with androgenetic alopecia: A randomized, comparative, clinical feasibility study using phototrichogram analysis

37 citations , February 2014 in “Journal of Dermatology”

This study found that topical valproic acid significantly increased hair count in male patients with moderate androgenetic alopecia compared to placebo over 24 weeks.

research Faculty Opinions recommendation of Topical valproic acid increases the hair count in male patients with androgenetic alopecia: a randomized, comparative, clinical feasibility study using phototrichogram analysis.

July 2014 in “Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature”

Applying valproic acid on the scalp increased hair growth in men with hair loss.

research Valproic acid and alopecia: A two-edged sword

2 citations , April 2017 in “Asian Journal of Psychiatry”

This review discusses the role of histone deacetylases in hearing loss, proposing potential pharmacological interventions, but reports no new clinical results.

research Valproic acid promotes human hair growth in in vitro culture model

48 citations , June 2013 in “Journal of Dermatological Science”

This study found that valproic acid promoted human hair growth by increasing β-catenin levels, suggesting it may be a potential therapeutic option for alopecia.

research Topical Valproate Solution for Hair Growth

2 citations , May 2018

In this study, researchers highlighted that while oral valproate often causes hair loss, preliminary experiments with topical valproic acid solution suggest its potential for hair regeneration, potentially offering fewer side effects and reduced cost compared to existing treatments.

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Community Join

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community Source for topical valproic acid?

2 upvotes 9 months ago

The conversation is about finding a source for topical valproic acid for hair regrowth. The user mentions PP405 and the unavailability of products from certain suppliers.

community Custom topicals: Does anyone here mix their own topical?

2 upvotes 6 years ago

The conversation is about creating a custom hair loss treatment by mixing Kirkland Minoxidil with latanoprost, sandalore, valproic acid, and RU58841. The user is seeking suggestions or advice on this mixture.

community New & Improved Hair Growth Stack for Maximum Results

5 upvotes 1 year ago

A user shared a hair growth stack using minoxidil sulfate, valproic acid, bimatoprost, blue copper peptide, and other ingredients, emphasizing a gel-based formula for better skin tolerance. Another user suggested adding a 5-alpha-reductase inhibitor like finasteride or dutasteride for more effective long-term results.

community Ordered PTD-DBM from tailor made

6 upvotes 5 years ago

The conversation discusses hair loss treatments, including finasteride, microneedling, minoxidil, and PTD-DBM. The user has not noticed significant regrowth and is considering cost-effective options like valproic acid.

community Better Than Minoxidil? Topical Sodium Valproate

50 upvotes 1 year ago

Topical sodium valproate may promote hair growth by inhibiting GSK3β, allowing beta-catenin to proliferate, but it has potential side effects and requires more research. The conversation also mentions skepticism about a product called Vdphlo1, which includes sodium valproate and other ingredients.

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