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research Erectile dysfunction from mechanisms to medicines with a focus on the application of topical Minoxidil

February 2023 in “Sexual Medicine Reviews”

This review explores the potential of topical minoxidil as a treatment for erectile dysfunction, indicating that while a mild erectile response was observed, evidence remains insufficient for confirmation.

research Systemic and Topical Factors Involved in the Production of Experimental Cutaneous Calcinosis11From the Institut de Médecine et de Chirurgie expérimentales, Université de Montréal, Montréal, Canada.

9 citations , July 1961 in “Journal of Investigative Dermatology”

This study found that localized skin calcification could be induced in adult rats through dihydrotachysterol treatment combined with topical trauma, offering an experimental model for calcifying scleroderma.

research Hair Growth Stimulation in Testosterone-Induced Alopecic Mice: A Comparative Study between Topical Clove Oil 10% Topical Minoxidil 5% Research ArticleJournal of the Faculty of Medicine BaghdadPrint ISSN: 0041-9419, Online ISSN: 2410-8057DOI: https://doi.org/10.32007/jfacmedbaghdad2977. Hair Growth Stimulation in Testosterone-Induced Alopecic Mice: A Comparative Study between Topical Clove oil 10% Topical Minoxidil 5%

June 2025 in “Journal of the Faculty of Medicine Baghdad”

This study found that Syzygium aromaticum oil may improve the anagen/telogen ratio in testosterone-induced alopecia in mice, indicating potential as an alternative treatment to minoxidil for androgenic alopecia.

research Lead, Mercury, and Arsenic Poisoning Due to Topical Use of Traditional Chinese Medicines

68 citations , May 2013 in “The American journal of medicine”

This report documents two cases of severe systemic poisoning from heavy metals after short-term use of traditional Chinese medicines for treating damaged or infected tissue.

research Emulgel Considered as Anovel Type of Dosage Form for Topical Application

2 citations , January 2024 in “Pakistan Journal of Life and Social Sciences (PJLSS)”

This study examines the use of emulgel-based systems as drug delivery vehicles for hydrophobic medications, noting their potential benefits in dermatological applications due to properties like easy spreadability, non-greasy texture, and prolonged shelf life.

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community 4 years of topicals and some oral medicine

14 upvotes 1 week ago

The user has been using various hair loss treatments for four years, including topical and oral minoxidil, topical finasteride, topical dutasteride, and RU58841, along with microneedling. They report some improvement in hair density but are considering additional options like a hair transplant to fill in the crown.

community Anyone use a custom topical from Skin Medicinals with latanoprost ?

in Technology 1 upvotes 11 months ago

The conversation discusses using a custom topical from Skin Medicinals containing latanoprost for hair loss, which helps move hairs into the anagen phase. The user is curious about the cost and effectiveness of this treatment.

community Any medicine to stop hairloss due to seborrheic dermatitis?

2 upvotes 1 year ago

Betnovate and mometasone furoate were tried for scalp issues, but Zoryve and Selsun shampoo were recommended for relief. Itraconazole was suggested for stronger treatment if topicals fail.

community EMA is re-examining Winlevi (clascoterone at lower concentration)

8 upvotes 1 year ago

Clascoterone in Winlevi, a topical AR antagonist, is being re-examined due to concerns about HPA axis suppression in adolescents, but it's unlikely to be banned for adult use in androgenetic alopecia (AGA). The European Medicines Agency recommended refusing Winlevi for acne vulgaris, but this may not affect Breezula's approval for AGA.

community Just got my first I-PRF Injection...

4 upvotes 4 years ago

A user shared their experience with hair loss treatments, including I-PRF injections, mesotherapy, and a topical solution containing Minoxidil and Finasteride. After experiencing side effects, they decided to stop the medicinal treatments and focus on natural alternatives like I-PRF, microneedling, and essential oils.

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Learn

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learn Hair Transplant

How much does a hair transplant cost? Hair transplant costs typically range from $1,000 to $25,000 depending on various factors.

learn SCUBE3

Is SCUBE3 available in topical or injectable form, and how is it usually applied in studies? SCUBE3 is not available as a topical or injectable treatment and is not an approved medicine. In the one published study, the protein was microinjected into mouse skin, including skin carrying grafted human scalp follicles; there are no human clinical trials.

learn Fluridil

Topical anti-androgen sold as a cosmetic lotion

How is Fluridil different from other DHT blockers like finasteride? Fluridil is a topical androgen-receptor blocker applied to the scalp, while finasteride is an oral 5-alpha-reductase inhibitor that lowers DHT throughout the body. Finasteride is FDA-approved and far better studied; Fluridil rests on one 43-man trial and is not licensed as a hair-loss medicine, so its long-term safety and effect size are unknown.

learn Pyrilutamide

Experimental topical anti-androgen, also known as KX-826

What is pyrilutamide, and how does it help with androgenic alopecia or hair loss caused by DHT? Pyrilutamide (KX-826) is an investigational topical antiandrogen designed to block DHT at the androgen receptor in the scalp. Its sponsor reported that a 2023 China Phase III of a 0.5% tincture did not beat placebo and that a 2026 Phase III stage of a 1.0% tincture did; none of the data are peer-reviewed and it is not approved as a medicine anywhere.

learn RU58841

Experimental topical anti-androgen sold as a research chemical

learn Cetirizine

Antihistamine allergy medicine

learn Neem Oil

Oil from the neem tree, used in traditional remedies

learn Finasteride

Topical or oral? Choosing between pills and lotions according to your case. In studies, topical finasteride gave much lower blood levels of the drug than tablets but still lowered blood DHT, and whether it causes fewer side effects has not been established. There is no FDA-approved topical finasteride, and the FDA warned about compounded versions in April 2025.

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