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    GlossaryTopical Calcineurin Inhibitors (topical immunomodulators)

    medications applied to skin to reduce immune responses

    Topical Calcineurin Inhibitors (TCIs) are medications applied to the skin to reduce inflammation and immune responses. They work by blocking the activity of calcineurin, a protein that activates T-cells in the immune system, making them useful in treating conditions like eczema and vitiligo. Unlike corticosteroids, TCIs do not cause skin thinning, making them a safer long-term option for sensitive areas.

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      community Fin/dut ONLY users, this has been my experience so far

      in Finasteride/Dutasteride  97 upvotes 1 week ago
      The user has been using finasteride for hair loss since January 2023, initially seeing improvement but now experiencing increased thinning. They are considering other factors like thyroid and insulin resistance and are seeking advice from long-term finasteride users, while some suggest trying dutasteride, minoxidil, or consulting a dermatologist for further evaluation.

      community Sensitive liver, topical fin safe to try?

      in Finasteride  98 upvotes 1 day ago
      Topical finasteride is considered safer for the liver than oral finasteride due to less systemic absorption, but regular liver function tests are advised. The user is concerned about liver health due to a history of NAFLD and is exploring topical finasteride as a safer alternative.

      community Topical Dutasteride Progress (2.5 months)

      in Is this regrowth?  3 upvotes 4 weeks ago
      A 21-year-old male is using a topical treatment for hair loss, including Dutasteride, Minoxidil, Tretinoin, Ketoconazole, and Hydrocortisone, along with derma rolling. He reports no side effects from the treatment and seeks feedback on its effectiveness for hair regrowth.