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April 2017 in “Journal of Investigative Dermatology” This study suggests that alkaline phosphatase-regulated expression of CCL5 contributes to the trichogenicity of human dermal papilla spheres.
January 2024 in “Biomaterials Research” This study found that human hair follicle dermal papilla cells cultivated as 3D spheroids in hexanoyl glycol chitosan-coated dishes formed hair-like structures, with minoxidil enhancing growth, and successfully integrated into artificial skin models, suggesting advancements for hair loss treatments and skin restoration therapies.
October 2013 in “Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature” Three-dimensional culture helps dermal papilla cells grow new human hair follicles.
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October 2013 in “Proceedings of the National Academy of Sciences of the United States of America” This study found that altering cell culture conditions to form three-dimensional papilla spheroids can restore the ability of human dermal papilla cells to induce hair growth in adult skin.
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January 2019 in “Annals of dermatology/Annals of Dermatology” STAT5 is crucial for hair growth in 3D cultured human dermal papilla cells.