105 citations
,
February 1996 in “Journal of biological chemistry/The Journal of biological chemistry”
In this study, sequences upstream of the TGM3gene were found to regulate epithelial-specific gene expression in keratinocytes, suggesting potential applications in gene therapy.
119 citations
,
November 2016 in “American journal of human genetics”
This study reports the discovery of mutations in the PADI3, TGM3, and TCHH genes as molecular genetic causes of uncombable hair syndrome in children, indicating an autosomal-recessive inheritance pattern.
January 2022 in “Acta dermatovenerologica Alpina, Pannonica et Adriatica (Tiskana izd.)”
This article presents an overview of uncombable hair syndrome, emphasizing its clinical and molecular characteristics and noting systemic manifestations such as neuropsychiatric, ophthalmic, and cardiopulmonary issues.
This review discusses the role of TGM3 in skin and hair follicle biology, human tumor pathology, and genetic abnormalities, and reports no novel results; the authors highlight its potential as a cancer diagnostic biomarker.